Cervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomolecules
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Adnane, M., Meade, K.G. & O’Farrelly, C. Cervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomolecules. Vet Res Commun 42, 255–263 (2018). https://doi.org/10.1007/s11259-018-9734-0Abstract
Cervico-vaginal mucus (CVM), the product of epithelial cells lining the uterus, cervix and vagina, is secreted to facilitate uterine lubrication and microbial clearance. Predominantly composed of water and mucins, CVM also contains high levels of immuno-active proteins such as immunoglobulin A (IgA), lactoferrin and lysozyme which protect against infection by blocking adhesion and mediating microbial killing. The repertoire of cytokines, chemokines and antimicrobial peptides is predominantly generated by the secretions of endometrial epithelial cells into the uterine lumen and concentrated in the CVM. The quantity and relative proportions of these inflammatory biomarkers are affected by diverse factors including the estrus cycle and health status of the animal and therefore potentially provide important diagnostic and prognostic indicators. We propose that measuring molecular signatures in bovine CVM could be a useful approach to identifying and monitoring genital tract pathologies in beef and dairy cows.Funder
Science Foundation Ireland; Health Research Board; Department of Agriculture, Food and the MarineGrant Number
12/Ia/1667; HRA_POR/2012/37; FIRM/ RSF/CoFoRD 2013–2016: ENRICH; FIRM/RSF/CoFoRD 2011-2015ae974a485f413a2113503eed53cd6c53
https://doi.org/10.1007/s11259-018-9734-0
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