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dc.contributor.authorAdnane, Mounir
dc.contributor.authorMeade, Kieran G
dc.contributor.authorO’Farrelly, Cliona
dc.date.accessioned2020-08-20T15:40:51Z
dc.date.available2020-08-20T15:40:51Z
dc.date.issued2018-08-16
dc.identifier.citationAdnane, M., Meade, K.G. & O’Farrelly, C. Cervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomolecules. Vet Res Commun 42, 255–263 (2018). https://doi.org/10.1007/s11259-018-9734-0en_US
dc.identifier.issn0165-7380
dc.identifier.issn1573-7446
dc.identifier.urihttp://hdl.handle.net/11019/2305
dc.descriptionpeer-revieweden_US
dc.description.abstractCervico-vaginal mucus (CVM), the product of epithelial cells lining the uterus, cervix and vagina, is secreted to facilitate uterine lubrication and microbial clearance. Predominantly composed of water and mucins, CVM also contains high levels of immuno-active proteins such as immunoglobulin A (IgA), lactoferrin and lysozyme which protect against infection by blocking adhesion and mediating microbial killing. The repertoire of cytokines, chemokines and antimicrobial peptides is predominantly generated by the secretions of endometrial epithelial cells into the uterine lumen and concentrated in the CVM. The quantity and relative proportions of these inflammatory biomarkers are affected by diverse factors including the estrus cycle and health status of the animal and therefore potentially provide important diagnostic and prognostic indicators. We propose that measuring molecular signatures in bovine CVM could be a useful approach to identifying and monitoring genital tract pathologies in beef and dairy cows.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesVeterinary Research Communications;42
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectCervico-vaginal mucusen_US
dc.subjectDiagnosisen_US
dc.subjectBiomarkersen_US
dc.subjectInflammationen_US
dc.titleCervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomoleculesen_US
dc.typeAnimationen_US
dc.identifier.doihttps://doi.org/10.1007/s11259-018-9734-0
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorHealth Research Boarden_US
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorGrantNumber12/Ia/1667en_US
dc.contributor.sponsorGrantNumberHRA_POR/2012/37en_US
dc.contributor.sponsorGrantNumberFIRM/ RSF/CoFoRD 2013–2016: ENRICHen_US
dc.contributor.sponsorGrantNumberFIRM/RSF/CoFoRD 2011-2015en_US
dc.source.volume42
dc.source.issue4
dc.source.beginpage255-263
refterms.dateFOA2020-08-20T15:40:52Z


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