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dc.contributor.authorGreen-Gomez, Marina
dc.contributor.authorPrado-Cabrero, Alfonso
dc.contributor.authorMoran, Rachel
dc.contributor.authorPower, Tommy
dc.contributor.authorGómez Gómez-Mascaraque, Laura
dc.contributor.authorStack, Jim
dc.contributor.authorNolan, John N.
dc.date.accessioned2020-11-03T17:16:22Z
dc.date.available2020-11-03T17:16:22Z
dc.date.issued2020-08-18
dc.identifier.citationGreen-Gomez, M.; Prado-Cabrero, A.; Moran, R.; Power, T.; Gómez-Mascaraque, L.G.; Stack, J.; Nolan, J.M. The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study. Antioxidants 2020, 9, 767. doi: https://doi.org/10.3390/antiox9080767en_US
dc.identifier.urihttp://hdl.handle.net/11019/2353
dc.descriptionpeer-revieweden_US
dc.description.abstractLutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561)en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesAntioxidants;vol 9
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectmeso-zeaxanthinen_US
dc.subjectZeaxanthinen_US
dc.subjectLuteinen_US
dc.subjectcarotenoid diacetatesen_US
dc.subjectbioavailabilityen_US
dc.subjectmicromicellesen_US
dc.titleThe Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Studyen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/antiox9080767
dc.identifier.piiantiox9080767
dc.contributor.sponsorHoward Foundation UKen_US
dc.contributor.sponsorWaterford Institute of Technology (WIT) President’s scholarship programen_US
dc.source.volume9
dc.source.issue8
dc.source.beginpage767
refterms.dateFOA2020-11-03T17:16:23Z
dc.source.journaltitleAntioxidants
dc.identifier.eissn2076-3921


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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International