The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study
dc.contributor.author | Green-Gomez, Marina | |
dc.contributor.author | Prado-Cabrero, Alfonso | |
dc.contributor.author | Moran, Rachel | |
dc.contributor.author | Power, Tommy | |
dc.contributor.author | Gómez Gómez-Mascaraque, Laura | |
dc.contributor.author | Stack, Jim | |
dc.contributor.author | Nolan, John N. | |
dc.date.accessioned | 2020-11-03T17:16:22Z | |
dc.date.available | 2020-11-03T17:16:22Z | |
dc.date.issued | 2020-08-18 | |
dc.identifier.citation | Green-Gomez, M.; Prado-Cabrero, A.; Moran, R.; Power, T.; Gómez-Mascaraque, L.G.; Stack, J.; Nolan, J.M. The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study. Antioxidants 2020, 9, 767. doi: https://doi.org/10.3390/antiox9080767 | en_US |
dc.identifier.uri | http://hdl.handle.net/11019/2353 | |
dc.description | peer-reviewed | en_US |
dc.description.abstract | Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561) | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.relation.ispartofseries | Antioxidants;vol 9 | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | meso-zeaxanthin | en_US |
dc.subject | Zeaxanthin | en_US |
dc.subject | Lutein | en_US |
dc.subject | carotenoid diacetates | en_US |
dc.subject | bioavailability | en_US |
dc.subject | micromicelles | en_US |
dc.title | The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/antiox9080767 | |
dc.identifier.pii | antiox9080767 | |
dc.contributor.sponsor | Howard Foundation UK | en_US |
dc.contributor.sponsor | Waterford Institute of Technology (WIT) President’s scholarship program | en_US |
dc.source.volume | 9 | |
dc.source.issue | 8 | |
dc.source.beginpage | 767 | |
refterms.dateFOA | 2020-11-03T17:16:23Z | |
dc.source.journaltitle | Antioxidants | |
dc.identifier.eissn | 2076-3921 |
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