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dc.contributor.authorGe, Huifang
dc.contributor.authorLin, Peixuan
dc.contributor.authorLuo, Taiduan
dc.contributor.authorYan, Zhiming
dc.contributor.authorXiao, Jianbo
dc.contributor.authorMiao, Song
dc.contributor.authorChen, Jichen
dc.date.accessioned2021-02-17T17:42:10Z
dc.date.available2021-02-17T17:42:10Z
dc.date.issued2020-07
dc.identifier.citationH Ge, P Lin, T Luo, Z Yan, J Xiao, S Miao, J Chen, Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients, Food Chemistry, 2020, 317, 126377. doi: https://doi.org/10.1016/j.foodchem.2020.126377en_US
dc.identifier.urihttp://hdl.handle.net/11019/2388
dc.descriptionhen_US
dc.descriptionpeer-revieweden_US
dc.description.abstractLigusticum chuanxiong extract-polylactic acid sustained-release microspheres (LCE-PLA) are fabricated in this study for enhancing both duration and hepatoprotective efficacy of the main bioactive ingredients. LCE-PLA in vitro release, cytotoxicity and in vivo hepatoprotective effect were discussed to evaluate its efficiency and functionality. Results demonstrated that the optimal drug-loading rate and encapsulation efficiency of tetramethylpyrazine (TMP, the main active ingredient) were 8.19%, 83.72%, respectively. The LCE-PLA in vitro release of TMP showed prolong 5-fold and in vitro cytotoxicity declined 25.00% compared with naked LCE. After 6 weeks of in vivo intervention in high fat diet mice, both liver aspartate aminotransferase and alanine aminotransferase levels were higher in LCE-PLA group than LCE group. The above results indicated that TMP had a higher bioavailability of hepatoprotection when encapsulation of LCE-PLA was applied. The current study has provided a promising novel way to enhance the efficacy of short half-life ingredients.en_US
dc.description.sponsorshipNational Natural Science Foundation of China
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofseriesFood Chemistry;317
dc.rights© 2020 Published by Elsevier Ltd.
dc.rightsAttribution-ShareAlike 4.0 International*
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectLigusticum chuanxiongen_US
dc.subjectsustained-releaseen_US
dc.subjectmicrospheresen_US
dc.subjecthigh fat dieten_US
dc.subjecthepatoprotective effecten_US
dc.titleFabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredientsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.foodchem.2020.126377
dc.contributor.sponsorNational Natural Science Foundation of Chinaen_US
dc.contributor.sponsorNatural Science Foundation of Fujian Provinceen_US
dc.contributor.sponsorGrantNumberNo. 31201350en_US
dc.contributor.sponsorGrantNumberNo. 2016J01105en_US
dc.source.volume317
dc.source.beginpage126377
refterms.dateFOA2021-02-17T17:42:11Z
dc.source.journaltitleFood Chemistry


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