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dc.contributor.authorO'Connor, Karen M.
dc.contributor.authorLucking, Eric F.
dc.contributor.authorBastiaanssen, Thomaz F.S.
dc.contributor.authorPeterson, Veronica L.
dc.contributor.authorCrispie, Fiona
dc.contributor.authorCotter, Paul D.
dc.contributor.authorClarke, Gerard
dc.contributor.authorCryan, John F.
dc.contributor.authorO'Halloran, Ken D.
dc.date.accessioned2021-04-11T16:37:52Z
dc.date.available2021-04-11T16:37:52Z
dc.date.issued2020-08-30
dc.identifier.citationK. M. O'Connor, E. F. Lucking, T. F. S. Bastiaanssen, V. L. Peterson, F. Crispie, P. D. Cotter, G. Clarke, J. F. Cryan, K. D. O'Halloran, Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats, EBioMedicine, Volume 59, 2020, https://doi.org/10.1016/j.ebiom.2020.102968en_US
dc.identifier.urihttp://hdl.handle.net/11019/2396
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if treatment with prebiotics ameliorates cardiorespiratory dysfunction in CIH-exposed rats. Methods Adult male rats were exposed to CIH (96 cycles/day, 6.0% O2 at nadir) for 14 consecutive days with and without prebiotic supplementation (fructo- and galacto-oligosaccharides) beginning two weeks prior to gas exposures. Findings CIH increased apnoea index and caused hypertension. CIH exposure had modest effects on the gut microbiota, decreasing the relative abundance of Lactobacilli species, but had no effect on microbial functional characteristics. Faecal short-chain fatty acid (SCFA) concentrations, plasma and brainstem pro-inflammatory cytokine concentrations and brainstem neurochemistry were unaffected by exposure to CIH. Prebiotic administration modulated gut microbiota composition and diversity, altering gut-metabolic (GMMs) and gut-brain (GBMs) modules and increased faecal acetic and propionic acid concentrations, but did not prevent adverse CIH-induced cardiorespiratory phenotypes. Interpretation CIH-induced cardiorespiratory dysfunction is not dependant upon changes in microbial functional characteristics and decreased faecal SCFA concentrations. Prebiotic-related modulation of microbial function and resultant increases in faecal SCFAs were not sufficient to prevent CIH-induced apnoea and hypertension in our model. Our results do not exclude the potential for microbiota-gut-brain axis involvement in OSA-related cardiorespiratory morbidity, but they demonstrate that in a relatively mild model of CIH, sufficient to evoke classic cardiorespiratory dysfunction, such changes are not obligatory for the development of morbidity, but may become relevant in the elaboration and maintenance of cardiorespiratory morbidity with progressive disease. Funding Department of Physiology and APC Microbiome Ireland, University College Cork, Ireland. APC Microbiome Ireland is funded by Science Foundation Ireland, through the Government's National Development Plan.en_US
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.relation.ispartofseriesEBioMedicine;
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectChronic intermittent hypoxiaen_US
dc.subjectPrebioticsen_US
dc.subjectApnoeaen_US
dc.subjectHypertensionen_US
dc.subjectAutonomic dysfunctionen_US
dc.subjectNeurochemistryen_US
dc.subjectShort-chain fatty acidsen_US
dc.subjectVagusen_US
dc.subjectMicrobiotaen_US
dc.titlePrebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult ratsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.ebiom.2020.102968
dc.contributor.sponsorScience Foundation Irelanden_US
refterms.dateFOA2021-04-11T16:37:52Z


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