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dc.contributor.authorLiu, Rui
dc.contributor.authorYang, Bo
dc.contributor.authorSTANTON, CATHERINE
dc.contributor.authorRoss, Paul
dc.contributor.authorZhao, Jianxin
dc.contributor.authorZhang, Hao
dc.contributor.authorChen, Wei
dc.date.accessioned2021-06-16T10:17:34Z
dc.date.available2021-06-16T10:17:34Z
dc.date.issued2020-08
dc.identifier.citationR. Liu, B. Yang, C. Stanton, R. P. Ross, J. Zhao, H. Zhang, W. Chen, Comparative genomics and gene-trait matching analysis of Bifidobacterium breve from Chinese children, Food Bioscience, 2020, 36, 100631 DOI: https://doi.org/10.1016/j.fbio.2020.100631en_US
dc.identifier.urihttp://hdl.handle.net/11019/2440
dc.descriptionpeer-revieweden_US
dc.description.abstractBifidobacterium breve is one of the dominant Bifidobacterial species in children. In the current work, 46 strains of B. breve isolated from fecal samples of Chinese children were analyzed using whole-genome sequencing and comparative genomics to explore their genetic diversity, as well as genotype and phenotype analysis for carbohydrate utilization and antibiotic tolerance. The phylogenetic tree was independent of region, age and feeding mode, and without any regularity in the clustering of carbohydrates and antibiotics at the genetic level. Based on genotypic-phenotypic correlation analysis, the diversity of glycosyl hydrolases and the ability of strains to metabolize carbohydrates corroborated the predominance of B. breve in the children's intestines. Simultaneously, the sensitivity of strains to antibiotics increased the understanding of its genetic features and provided a potential basis for safety evaluation.en_US
dc.description.sponsorshipNational Natural Science Foundation of China
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofseriesFood Bioscience;
dc.rights© 2020 Elsevier Ltd. All rights reserved.
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBifidobacterium breveen_US
dc.subjectComparative genomicsen_US
dc.subjectCarbohydrate metabolismen_US
dc.subjectAntibiotic resistanceen_US
dc.subjectGenomic diversityen_US
dc.titleComparative genomics and gene-trait matching analysis of Bifidobacterium breve from Chinese childrenen_US
dc.typeArticleen_US
dc.embargo.terms2021/05/11en_US
dc.identifier.doihttps://doi.org/10.1016/j.fbio.2020.100631
dc.contributor.sponsorNational Natural Science Foundation of Chinaen_US
dc.contributor.sponsorNational First-Class Discipline Program of Food Science and Technologyen_US
dc.contributor.sponsorthe Fundamental Research Funds for the Central Universitiesen_US
dc.contributor.sponsorthe Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Provinceen_US
dc.contributor.sponsorGuangzhou Biostime Institute of Nutrition & Careen_US
dc.contributor.sponsorGrantNumber31771953en_US
dc.contributor.sponsorGrantNumber31820103010en_US
dc.contributor.sponsorGrantNumber31801521en_US
dc.contributor.sponsorGrantNumberJUFSTR20180102en_US
dc.contributor.sponsorGrantNumberJUSRP11733en_US
dc.contributor.sponsorGrantNumberBINCMCF1201en_US
dc.source.volume36
dc.source.beginpage100631
refterms.dateFOA2021-05-11T00:00:00Z
dc.source.journaltitleFood Bioscience


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