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dc.contributor.authorClarke, Gerard
dc.contributor.authorFitzgerald, Peter
dc.contributor.authorHennessy, Alan A.
dc.contributor.authorCassidy, Eugene M.
dc.contributor.authorQuigley M., Eamonn M.
dc.contributor.authorRoss, Paul
dc.contributor.authorSTANTON, CATHERINE
dc.contributor.authorCryan, John F.
dc.contributor.authorDinan, Timothy G.
dc.date.accessioned2021-07-15T10:29:04Z
dc.date.available2021-07-15T10:29:04Z
dc.date.issued2021-01-04
dc.identifier.citationGerard Clarke, Peter Fitzgerald, Alan A. Hennessy, Eugene M. Cassidy, Eamonn M.M. Quigley, Paul Ross, Catherine Stanton, John F. Cryan, Timothy G. Dinan, Marked elevations in pro-infl ammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome, Journal of Lipid Research, 2020, 51(5), 1186-1192. DOI:https://doi.org/10.1194/jlr.P000695en_US
dc.identifier.urihttp://hdl.handle.net/11019/2468
dc.descriptionPeer-Revieweden_US
dc.description.abstractIrritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder referred to gastroenterologists. Although the pathophysiology remains unclear, accumulating evidence points to the presence of low-level immune activation both in the gut and systemically. Circulating polyunsaturated fatty acids (PUFA) have recently attracted attention as being altered in a variety of disease states. Arachidonic acid (AA), in particular, has been implicated in the development of a pro-inflammatory profile in a number of immune-related disorders. AA is the precursor of a number of important immunomodulatory eicosanoids, including prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). We investigated the hypothesis that elevated plasma AA concentrations in plasma contribute to the proposed pro-inflammatory profile in IBS. Plasma AA and related PUFA were quantified by gas chromatography analysis in IBS patients and controls. Both PGE2 and LTB4 were measured in serum using commercially available ELISA assays. AA concentrations were elevated in our patient cohort compared with healthy controls. Moreover, we demonstrated that this disturbance in plasma AA concentrations leads to downstream elevations in eicosanoids. Together, our data identifies a novel proinflammatory mechanism in irritable bowel syndrome and also suggests that elevated arachidonic acid levels in plasma may serve as putative biological markers in this condition.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesJournal of Lipid Research;51
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectarachidonic aciden_US
dc.subjectbiological markeren_US
dc.subjecteicosanoid gasen_US
dc.subjectchromatographyen_US
dc.subjectIBSen_US
dc.subjectpro-inflammatory profileen_US
dc.titleMarked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndromeen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1194/jlr.P000695
refterms.dateFOA2021-07-15T10:29:05Z


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