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dc.contributor.authorJohnson, Athira
dc.contributor.authorKong, Fanbin
dc.contributor.authorMiao, Song
dc.contributor.authorLin, Hong‑Ting Victor
dc.contributor.authorThomas, Sabu
dc.contributor.authorHuang, Yi‑Cheng
dc.contributor.authorKong, Zwe‑Ling
dc.date.accessioned2021-07-21T15:04:52Z
dc.date.available2021-07-21T15:04:52Z
dc.date.issued2020-10-22
dc.identifier.citationJohnson, A., Kong, F., Miao, S. et al. Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment. Sci Rep 10, 18037 (2020). https://doi.org/10.1038/s41598-020-74845-9en_US
dc.identifier.urihttp://hdl.handle.net/11019/2494
dc.descriptionpeer-revieweden_US
dc.description.abstractPeriodontitis is an infammatory disease that can lead to the periodontal pocket formation and tooth loss. This study was aimed to develop antimicrobials loaded hydrogels composed of cellulose nanofbers (CNF) and κ-carrageenan oligosaccharides (CO) nanoparticles for the treatment of periodontitis. Two antimicrobial agents such as surfactin and Herbmedotcin were selected as the therapeutic agents and the hydrogels were formulated based on the increasing concentration of surfactin. The proposed material has high thermal stability, controlled release, and water absorption capacity. This study was proceeded by investigating the in vitro antibacterial and anti-infammatory properties of the hydrogels. This material has strong antibacterial activity against periodontal pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum, and Pseudomonas aeruginosa. Moreover, a signifcant increase in malondialdehyde (MDA) production and a decrease in bioflm formation and metabolic activity of the bacteria was observed in the presence of hydrogel. Besides, it reduced the reactive oxygen species (ROS) generation, transcription factor, and cytokines production in human gingival fbroblast cells (HGF) under infammatory conditions. In conclusion, the hydrogels were successfully developed and proven to have antibacterial and anti-infammatory properties for the treatment of periodontitis. Thus, it can be used as an excellent candidate for periodontitis treatment.en_US
dc.description.sponsorshipCenter of Excellence for the Oceans, National Taiwan Ocean University
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesScientific Reports;18037
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectTherapeutic efectsen_US
dc.subjectantibioticsen_US
dc.subjectcellulose nanofiberen_US
dc.subjectκ‑carrageenan oligosaccharide composite hydrogelsen_US
dc.subjectperiodontitis treatmenten_US
dc.titleTherapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatmenten_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1038/s41598-020-74845-9
dc.source.volume10
dc.source.issue1
refterms.dateFOA2021-07-21T15:04:52Z
dc.source.journaltitleScientific Reports


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