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dc.contributor.authorMurru, Elisabetta
dc.contributor.authorCarta, Gianfranca
dc.contributor.authorCordeddu, Lina
dc.contributor.authorMelis, Maria
dc.contributor.authorDesogus, Erika
dc.contributor.authorAnsar, Hastimansooreh
dc.contributor.authorChilliard, Yves
dc.contributor.authorFerlay, Anne
dc.contributor.authorStanton, Catherine
dc.contributor.authorCoakley, Mairéad
dc.contributor.authorRoss, R.
dc.contributor.authorPiredda, Giovanni
dc.contributor.authorAddis, Margherita
dc.contributor.authorMele, Maria
dc.contributor.authorCannelli, Giorgio
dc.contributor.authorBanni, Sebastiano
dc.contributor.authorManca, Claudia
dc.date.accessioned2021-07-27T14:53:16Z
dc.date.available2021-07-27T14:53:16Z
dc.date.issued2018-06-11
dc.identifier.citationMurru, E.; Carta, G.; Cordeddu, L.; Melis, M.P.; Desogus, E.; Ansar, H.; Chilliard, Y.; Ferlay, A.; Stanton, C.; Coakley, M.; Ross, R.P.; Piredda, G.; Addis, M.; Mele, M.C.; Cannelli, G.; Banni, S.; Manca, C. Dietary Conjugated Linoleic Acid-Enriched Cheeses Influence the Levels of Circulating n-3 Highly Unsaturated Fatty Acids in Humans. Int. J. Mol. Sci. 2018, 19, 1730. https://doi.org/10.3390/ijms19061730en_US
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11019/2519
dc.descriptionpeer-revieweden_US
dc.description.abstractn-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance and the inflammatory response. We investigated changes to the n-3 HUFA score of healthy adults, induced by different types and amounts of conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for different periods of time, compared to dietary fish oil (FO) pills (500 mg, each containing 100 mg of eicosapentaenoic and docosahexaenoic acids—EPA+DHA) or α-linolenic acid (ALA)-rich linseed oil (4 g, containing 2 g of ALA). A significant increase in the n-3 HUFA score was observed, in a dose-dependent manner, after administration of the FO supplement. In terms of the impact on the n-3 HUFA score, the intake of ENCH cheese (90 g/day) for two or four weeks was equivalent to the administration of one or two FO pills, respectively. Conversely, the linseed oil intake did not significantly impact the n-3 HUFA score. Feeding ENCH cheeses from different sources (bovine, ovine and caprine) for two months improved the n-3 HUFA score by increasing plasma DHA, and the effect was proportional to the CLA content in the cheese. We suggest that the improved n-3 HUFA score resulting from ENCH cheese intake may be attributed to increased peroxisome proliferator-activated receptor alpha (PPAR-α) activity. This study demonstrates that natural ENCH cheese is an alternative nutritional source of n-3 HUFA in humans.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMolecular Sciences;19
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectconjugated linoleic acids (CLA)en_US
dc.subjectcheeseen_US
dc.subjectruminanten_US
dc.subjecthighly unsaturated fatty acids (HUFA)en_US
dc.subjectfatty acids (FA)en_US
dc.subjectplasmaen_US
dc.subjectclinical trialen_US
dc.titleDietary Conjugated Linoleic Acid-Enriched Cheeses Influence the Levels of Circulating n-3 Highly Unsaturated Fatty Acids in Humansen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/ijms19061730
dc.contributor.sponsorEuropean Unionen_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorGrantNumberQLK1-2002-02362en_US
dc.contributor.sponsorGrantNumberINNOVA.RE-WP2.3-P.O.R.-F.E.S.R. 2007/2013en_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.source.volume19
dc.source.issue6
dc.source.beginpage1730
refterms.dateFOA2021-07-27T14:53:17Z


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