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dc.contributor.authorKosanovic, Dejana
dc.contributor.authorGrogan, Helen
dc.contributor.authorKavanagh, Kevin
dc.date.accessioned2021-08-03T15:26:50Z
dc.date.available2021-08-03T15:26:50Z
dc.date.issued2020-09
dc.identifier.citationKosanovic, H. Grogan, K. Kavanagh, Exposure of Agaricus bisporus to Trichoderma aggressivum f. europaeum leads to growth inhibition and induction of an oxidative stress response, Fungal Biology, 2020, 124 (9), 814-820. DOI: https://doi.org/10.1016/j.funbio.2020.07.003en_US
dc.identifier.urihttp://hdl.handle.net/11019/2537
dc.descriptionpeer-revieweden_US
dc.description.abstractGreen mould disease of mushroom, Agaricus bisporus,is caused by Trichodermaspecies and can result in substantial crop losses.Label free proteomic analysis of changes in the abundance of A. bisporusproteins following exposure to T. aggressivumsupernatantin vitroindicated increased abundance of proteins associated with an oxidative stress response (zinc ion binding (+6.6 fold); peroxidase activity (5.3-fold); carboxylic ester hydrolase (+2.4 fold); dipeptidase (+3.2 fold); [2Fe-2S] cluster assembly (+3.3 fold)). Proteins that decreased in relative abundance were associated with growth: structural constituent of ribosome, translation (-12 fold), deadenylation-dependent decapping of nuclear-transcribed mRNA (-3.4 fold), and small GTPase mediated signal transduction (-2.6 fold). In vivoanalysis revealed that 10-4 T. aggressivuminoculum decreased the mushroom yield by 29% to 56% and 10-3 T. aggressivuminoculum decreased the mushroom yield by 68% to 100%. Proteins that increased in abundance in A. bisporusin vivofollowing exposure to T. aggressivumindicated an oxidative stress response and included proteins with pyruvate kinase activity (+2.6 fold) and hydrolase activity (+2.1 fold)). The results indicate that exposure of A. bisporusmycelium to T. aggressivum in vitroand in vivoresulted in an oxidative stress response and reduction in growth.en_US
dc.description.sponsorshipIrish Research Council
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofseriesFungal Biology;124
dc.rights© 2020 The Authors. Published by Elsevier Ltd on behalf of British Mycological Society.
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAgaricus bisporusen_US
dc.subjectTrichoderma aggressivumen_US
dc.subjectProteomicsen_US
dc.subjectHost–pathogen interactionsen_US
dc.titleExposure of Agaricus bisporus to Trichoderma aggressivum f. europaeum leads to growth inhibition and induction of an oxidative stress responseen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.funbio.2020.07.003
dc.contributor.sponsorIrish Research Councilen_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorGrantNumberGOIPD/2018/115en_US
dc.contributor.sponsorGrantNumber12/RI/2346en_US
dc.source.volume124
dc.source.issue9
dc.source.beginpage814
dc.source.endpage820
refterms.dateFOA2021-08-03T15:26:51Z
dc.source.journaltitleFungal Biology


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