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dc.contributor.authorChoudhary, Alka
dc.contributor.authorNaughton, Lynn
dc.contributor.authorMontánchez, Itxaso
dc.contributor.authorDobson, Alan
dc.contributor.authorRai, Dilip
dc.date.accessioned2021-08-04T14:48:18Z
dc.date.available2021-08-04T14:48:18Z
dc.date.issued2017-08-28
dc.identifier.citationChoudhary, A.; Naughton, L.M.; Montánchez, I.; Dobson, A.D.W.; Rai, D.K. Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials. Mar. Drugs 2017, 15, 272. https://doi.org/10.3390/md15090272en_US
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/11019/2548
dc.descriptionmain articleen_US
dc.description.abstractThe marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMarine Drugs;15
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectantimicrobialen_US
dc.subjectmarine natural products (MNPs)en_US
dc.subjectsecondary metabolitesen_US
dc.subjectantibacterialen_US
dc.subjectantifungalen_US
dc.subjectgenome miningen_US
dc.titleCurrent Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobialsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/md15090272
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorGrantNumberFIRM 11/F/009en_US
dc.source.volume15
dc.source.issue9
dc.source.beginpage272
refterms.dateFOA2021-08-04T14:48:19Z


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