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dc.contributor.authorGilmartin, Sarah
dc.contributor.authorO’Brien, Nora
dc.contributor.authorGiblin, Linda
dc.date.accessioned2021-08-10T14:45:48Z
dc.date.available2021-08-10T14:45:48Z
dc.date.issued2020-06-05
dc.identifier.citationGilmartin, S.; O’Brien, N.; Giblin, L. Whey for Sarcopenia; Can Whey Peptides, Hydrolysates or Proteins Play a Beneficial Role? Foods 2020, 9, 750. https://doi.org/10.3390/foods9060750en_US
dc.identifier.urihttp://hdl.handle.net/11019/2565
dc.descriptionpeer revieweden_US
dc.description.abstractAs the human body ages, skeletal muscle loses its mass and strength. It is estimated that in 10% of individuals over the age of 60, this muscle frailty has progressed to sarcopenia. Biomarkers of sarcopenia include increases in inflammatory markers and oxidative stress markers and decreases in muscle anabolic markers. Whey is a high-quality, easily digested dairy protein which is widely used in the sports industry. This review explores the evidence that whey protein, hydrolysates or peptides may have beneficial effects on sarcopenic biomarkers in myoblast cell lines, in aged rodents and in human dietary intervention trials with the older consumer. A daily dietary supplementation of 35 g of whey is likely to improve sarcopenic biomarkers in frail or sarcopenia individuals. Whey supplementation, consumed by an older, healthy adult certainly improves muscle mTOR signaling, but exercise appears to have the greatest benefit to older muscle. In vitro cellular assays are central for bioactive and bioavailable peptide identification and to determine their mechanism of action on ageing muscle.en_US
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine, Ireland
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesFoods;vol 9
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectsarcopeniaen_US
dc.subjectwhey proteinen_US
dc.subjectmuscleen_US
dc.subjectC2C12en_US
dc.subjectaged animalsen_US
dc.subjectolder adulten_US
dc.subjectexerciseen_US
dc.titleWhey for Sarcopenia; Can Whey Peptides, Hydrolysates or Proteins Play a Beneficial Role?en_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/foods9060750
dc.identifier.piifoods9060750
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorTeagasc Walsh Fellowship Programmeen_US
dc.contributor.sponsorGrantNumberFIRM 15F604-TOMIen_US
dc.contributor.sponsorGrantNumber16/RC/3835-VistaMilken_US
dc.source.volume9
dc.source.issue6
dc.source.beginpage750
refterms.dateFOA2021-08-10T14:45:48Z
dc.source.journaltitleFoods
dc.identifier.eissn2304-8158


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