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dc.contributor.authorMorais, Livia H.
dc.contributor.authorGolubeva, Anna V.
dc.contributor.authorMoloney, Gerard M
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.date.accessioned2021-08-16T12:01:12Z
dc.date.available2021-08-16T12:01:12Z
dc.date.issued2020-08-20
dc.identifier.citationMorais LH, Golubeva AV, Moloney GM, et al. Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse. Current Biology 2020;30(19):3761-74 e6. doi: https://doi.org/10.1016/j.cub.2020.07.044 [published Online First: 2020/08/22]en_US
dc.identifier.urihttp://hdl.handle.net/11019/2568
dc.descriptionpeer-revieweden_US
dc.description.abstractBirth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. Moreover, alterations of the microbiome have been shown to affect neurodevelopmental trajectories. However, the long-term effects of C-section on neurobehavioral processes remain unknown. Here, we demonstrated that birth by C-section results in marked but transient changes in microbiome composition in the mouse, in particular, the abundance of Bifidobacterium spp. was depleted in early life. Mice born by C-section had enduring social, cognitive, and anxiety deficits in early life and adulthood. Interestingly, we found that these specific behavioral alterations induced by the mode of birth were also partially corrected by co-housing with vaginally born mice. Finally, we showed that supplementation from birth with a Bifidobacterium breve strain, or with a dietary prebiotic mixture that stimulates the growth of bifidobacteria, reverses selective behavioral alterations in C-section mice. Taken together, our data link the gut microbiota to behavioral alterations in C-section-born mice and suggest the possibility of developing adjunctive microbiota-targeted therapies that may help to avert long-term negative consequences on behavior associated with C-section birth mode.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCurrent Biology;30
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectmicrobiotaen_US
dc.subjectbehaviouren_US
dc.subjectgut-brain axisen_US
dc.subjectCaesarean sectionen_US
dc.subjectprebioticsen_US
dc.subjectprobioticsen_US
dc.subjectco-housingen_US
dc.subjectmicrobiota gut brain axisen_US
dc.titleEnduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouseen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.cub.2020.07.044
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorEuropean Unionen_US
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorScience without Bordersen_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.contributor.sponsorGrantNumberFP7/2007-2013en_US
dc.contributor.sponsorGrantNumber11601-13-2en_US
refterms.dateFOA2021-08-16T12:01:13Z


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