Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions
Author
Gallagher, LouiseSmith, Alanna
Kavanagh, Kevin
Devereux, Michael
Colleran, John
Breslin, Carmel
Richards, Karl G.
McCann, Malachy
Rooney, A. Denise
Date
2021-06-14
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Gallagher L, Smith A, Kavanagh K, et al. Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry 2021;3(2):672-86. doi: https://doi.org/10.3390/chemistry3020047Abstract
Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/ HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)- octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility.Funder
Department of Agriculture, Food and the Marine; Monaghan County CouncilGrant Number
RSF 07545ae974a485f413a2113503eed53cd6c53
https://doi.org/10.3390/chemistry3020047
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