Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions
dc.contributor.author | Gallagher, Louise | |
dc.contributor.author | Smith, Alanna | |
dc.contributor.author | Kavanagh, Kevin | |
dc.contributor.author | Devereux, Michael | |
dc.contributor.author | Colleran, John | |
dc.contributor.author | Breslin, Carmel | |
dc.contributor.author | Richards, Karl G. | |
dc.contributor.author | McCann, Malachy | |
dc.contributor.author | Rooney, A. Denise | |
dc.date.accessioned | 2021-11-22T15:11:43Z | |
dc.date.available | 2021-11-22T15:11:43Z | |
dc.date.issued | 2021-06-14 | |
dc.identifier.citation | Gallagher L, Smith A, Kavanagh K, et al. Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry 2021;3(2):672-86. doi: https://doi.org/10.3390/chemistry3020047 | en_US |
dc.identifier.uri | http://hdl.handle.net/11019/2640 | |
dc.description | peer-reviewed | en_US |
dc.description.abstract | Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/ HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)- octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility. | en_US |
dc.description.sponsorship | Irish Department of Agriculture Food and Marine | |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.relation.ispartofseries | Chemistry;3 | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | hydrogel | en_US |
dc.subject | alginate | en_US |
dc.subject | BSA | en_US |
dc.subject | glutaraldehyde | en_US |
dc.subject | silver | en_US |
dc.subject | antimicrobal | en_US |
dc.title | Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/chemistry3020047 | |
dc.identifier.pii | chemistry3020047 | |
dc.contributor.sponsor | Department of Agriculture, Food and the Marine | en_US |
dc.contributor.sponsor | Monaghan County Council | en_US |
dc.contributor.sponsorGrantNumber | RSF 07545 | en_US |
dc.source.volume | 3 | |
dc.source.issue | 2 | |
dc.source.beginpage | 672 | |
dc.source.endpage | 686 | |
refterms.dateFOA | 2021-11-22T15:11:44Z | |
dc.source.journaltitle | Chemistry | |
dc.identifier.eissn | 2624-8549 |