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dc.contributor.authorGallagher, Louise
dc.contributor.authorSmith, Alanna
dc.contributor.authorKavanagh, Kevin
dc.contributor.authorDevereux, Michael
dc.contributor.authorColleran, John
dc.contributor.authorBreslin, Carmel
dc.contributor.authorRichards, Karl G.
dc.contributor.authorMcCann, Malachy
dc.contributor.authorRooney, A. Denise
dc.date.accessioned2021-11-22T15:11:43Z
dc.date.available2021-11-22T15:11:43Z
dc.date.issued2021-06-14
dc.identifier.citationGallagher L, Smith A, Kavanagh K, et al. Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry 2021;3(2):672-86. doi: https://doi.org/10.3390/chemistry3020047en_US
dc.identifier.urihttp://hdl.handle.net/11019/2640
dc.descriptionpeer-revieweden_US
dc.description.abstractCalcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/ HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)- octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility.en_US
dc.description.sponsorshipIrish Department of Agriculture Food and Marine
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesChemistry;3
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjecthydrogelen_US
dc.subjectalginateen_US
dc.subjectBSAen_US
dc.subjectglutaraldehydeen_US
dc.subjectsilveren_US
dc.subjectantimicrobalen_US
dc.titlePreparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ionsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/chemistry3020047
dc.identifier.piichemistry3020047
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorMonaghan County Councilen_US
dc.contributor.sponsorGrantNumberRSF 07545en_US
dc.source.volume3
dc.source.issue2
dc.source.beginpage672
dc.source.endpage686
refterms.dateFOA2021-11-22T15:11:44Z
dc.source.journaltitleChemistry
dc.identifier.eissn2624-8549


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