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dc.contributor.authorGarcia-Gutierrez, Enriqueta
dc.contributor.authorMayer, Melinda J.
dc.contributor.authorCotter, Paul D.
dc.contributor.authorNarbad, Arjan
dc.date.accessioned2021-11-22T17:40:43Z
dc.date.available2021-11-22T17:40:43Z
dc.date.issued2019-05-22
dc.identifier.citationEnriqueta Garcia-Gutierrez, Melinda J. Mayer, Paul D. Cotter & Arjan Narbad (2019) Gut microbiota as a source of novel antimicrobials, Gut Microbes, 10:1, 1-21, DOI: 10.1080/19490976.2018.1455790en_US
dc.identifier.issn1949-0976
dc.identifier.urihttp://hdl.handle.net/11019/2645
dc.descriptionpeer revieweden_US
dc.description.abstractBacteria, Archaea, Eukarya and viruses coexist in the human gut, and this coexistence is functionally balanced by symbiotic or antagonistic relationships. Antagonism is often characterized by the production of antimicrobials against other organisms occupying the same environmental niche. Indeed, close co-evolution in the gut has led to the development of specialized antimicrobials, which is attracting increased attention as these may serve as novel alternatives to antibiotics and thereby help to address the global problem of antimicrobial resistance. The gastrointestinal (GI) tract is especially suitable for finding novel antimicrobials due to the vast array of microbes that inhabit it, and a considerable number of antimicrobial producers of both wide and narrow spectrum have been described. In this review, we summarize some of the antimicrobial compounds that are produced by bacteria isolated from the gut environment, with a special focus on bacteriocins. We also evaluate the potential therapeutic application of these compounds to maintain homeostasis in the gut and the biocontrol of pathogenic bacteria.en_US
dc.description.sponsorshipTeagasc
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofseriesGut Microbes;Vol. 10
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectantimicrobialen_US
dc.subjectbacteriocinen_US
dc.subjectantimicrobalen_US
dc.subjectbacteriocinen_US
dc.subjectgastrointestinal tracten_US
dc.subjectmicrobiomeen_US
dc.subjectbiocontrolen_US
dc.subjectantibiotic resistanceen_US
dc.subjectprobioticen_US
dc.subjecthomeostasisen_US
dc.titleGut microbiota as a source of novel antimicrobialsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1080/19490976.2018.1455790
dc.identifier.pii10.1080/19490976.2018.1455790
dc.contributor.sponsorTeagascen_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorBiotechnology and Biological Sciences Research Councilen_US
dc.contributor.sponsorGrantNumber2015066en_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.contributor.sponsorGrantNumberSFI/11/PI/1137en_US
dc.contributor.sponsorGrantNumberBB/J004529/1en_US
dc.source.volume10
dc.source.issue1
dc.source.beginpage1
dc.source.endpage21
refterms.dateFOA2021-11-22T17:40:44Z
dc.source.journaltitleGut Microbes
dc.identifier.eissn1949-0984


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