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dc.contributor.authorLynn, David J
dc.contributor.authorChan, Calvin
dc.contributor.authorNaseer, Misbah
dc.contributor.authorYau, Melissa
dc.contributor.authorLo, Raymond
dc.contributor.authorSribnaia, Anastasia
dc.contributor.authorRing, Giselle
dc.contributor.authorQue, Jaimmie
dc.contributor.authorWee, Kathleen
dc.contributor.authorWinsor, Geoffrey L
dc.contributor.authorLaird, Matthew R
dc.contributor.authorBreuer, Karin
dc.contributor.authorForoushani, Amir K
dc.contributor.authorBrinkman, Fiona S. L.
dc.contributor.authorHancock, Robert EW
dc.date.accessioned2012-11-30T12:35:26Z
dc.date.available2012-11-30T12:35:26Z
dc.date.issued2010-08-20
dc.identifier.citationCurating the innate immunity interactome. Lynn, David J. et al. BMC Systems Biology, 2010, 4(1):117. doi:10.1186/1752-0509-4-117en_GB
dc.identifier.urihttp://hdl.handle.net/11019/265
dc.identifier.urihttp://dx.doi.org/10.1186/1752-0509-4-117
dc.descriptionpeer-reviewed
dc.description.abstractBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks. Systems biology approaches promise to shed new light on the regulation of innate immunity through the analysis and modelling of these networks. A key initial step in this process is the contextual cataloguing of the components of this system and the molecular interactions that comprise these networks. InnateDB (http://www.innatedb.com) is a molecular interaction and pathway database developed to facilitate systems-level analyses of innate immunity. Results: Here, we describe the InnateDB curation project, which is manually annotating the human and mouse innate immunity interactome in rich contextual detail, and present our novel curation software system, which has been developed to ensure interactions are curated in a highly accurate and data-standards compliant manner. To date, over 13,000 interactions (protein, DNA and RNA) have been curated from the biomedical literature. Here, we present data, illustrating how InnateDB curation of the innate immunity interactome has greatly enhanced network and pathway annotation available for systems-level analysis and discuss the challenges that face such curation efforts. Significantly, we provide several lines of evidence that analysis of the innate immunity interactome has the potential to identify novel signalling, transcriptional and post-transcriptional regulators of innate immunity. Additionally, these analyses also provide insight into the cross-talk between innate immunity pathways and other biological processes, such as adaptive immunity, cancer and diabetes, and intriguingly, suggests links to other pathways, which as yet, have not been implicated in the innate immune response. Conclusions: In summary, curation of the InnateDB interactome provides a wealth of information to enable systems-level analysis of innate immunity.en_GB
dc.description.sponsorshipGenome BC - Pathogenomics of Innate Immunity (PI2) project; Foundation for the National Institutes of Health and the Canadian Institutes of Health Research - Grand Challenges in Global Health Research Initiative (Grand Challenges ID: 419); Teagasc; DJL was funded in part during this project by a postdoctoral trainee award from the Michael Smith Foundation for Health Research (MSFHR); FSLB is a Canadian Institutes of Health Research (CIHR) New Investigator and a MSFHR Senior Scholar; REWH holds a Canada Research Chair (CRC)
dc.language.isoenen_GB
dc.publisherBiomed Central
dc.relation.ispartofseriesBMC Systems Biology
dc.subjectInnate immunity analysis
dc.subjectCuration software system
dc.subjectInnateDB
dc.titleCurating the innate immunity interactomeen_GB
dc.typeArticleen_GB
dc.identifier.rmisGEAB-1002-5694
dc.identifier.rmisGEAB-0203-5756
refterms.dateFOA2018-01-12T07:40:10Z


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