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dc.contributor.authorMcCann, Angela
dc.contributor.authorRyan, Feargal J.
dc.contributor.authorStockdale, Stephen R.
dc.contributor.authorDalmasso, Marion
dc.contributor.authorBlake, Tony
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorSTANTON, CATHERINE
dc.contributor.authorMills, Susan
dc.contributor.authorRoss, Paul R.
dc.contributor.authorHill, Colin
dc.date.accessioned2021-12-09T14:31:15Z
dc.date.available2021-12-09T14:31:15Z
dc.date.issued2018-05-07
dc.identifier.citationMcCann A, Ryan FJ, Stockdale SR, Dalmasso M, Blake T, Ryan CA, Stanton C, Mills S, Ross PR, Hill C. 2018. Viromes of one year old infants reveal the impact of birth mode on microbiome diversity. PeerJ 6:e4694 https://doi.org/10.7717/peerj.4694en_US
dc.identifier.issn2167-8359
dc.identifier.urihttp://hdl.handle.net/11019/2688
dc.descriptionpeer-revieweden_US
dc.description.abstractEstablishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU’s (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome.en_US
dc.language.isoenen_US
dc.publisherPeerJen_US
dc.relation.ispartofseriesPeerJ;4694
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectViromeen_US
dc.subjectInfanten_US
dc.subjectBirth modeen_US
dc.subjectBacteriophageen_US
dc.subjectMetagenomicsen_US
dc.subjectMicrobiomeen_US
dc.titleViromes of one year old infants reveal the impact of birth mode on microbiome diversityen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.7717/peerj.4694
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorGrantNumber12/RC/2273en_US
dc.source.volume6
dc.source.beginpagee4694
refterms.dateFOA2021-12-09T14:31:16Z


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