Show simple item record

dc.contributor.authorMencía-Ares, Oscar
dc.contributor.authorCabrera-Rubio, Raúl
dc.contributor.authorCobo-Díaz, José F
dc.contributor.authorÁlvarez-Ordóñez, Avelino
dc.contributor.authorGómez-García, Manuel
dc.contributor.authorPuente, Héctor
dc.contributor.authorCotter, Paul D
dc.contributor.authorCrispie, Fiona
dc.contributor.authorCarvajal, Ana
dc.contributor.authorRubio, Pedro
dc.contributor.authorArgüello, Héctor
dc.date.accessioned2021-12-20T17:07:04Z
dc.date.available2021-12-20T17:07:04Z
dc.date.issued2020-11-19
dc.identifier.citationMencía-Ares, O., Cabrera-Rubio, R., Cobo-Díaz, J.F. et al. Antimicrobial use and production system shape the fecal, environmental, and slurry resistomes of pig farms. Microbiome 8, 164 (2020). https://doi.org/10.1186/s40168-020-00941-7en_US
dc.identifier.urihttp://hdl.handle.net/11019/2722
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground The global threat of antimicrobial resistance (AMR) is a One Health problem impacted by antimicrobial use (AMU) for human and livestock applications. Extensive Iberian swine production is based on a more sustainable and eco-friendly management system, providing an excellent opportunity to evaluate how sustained differences in AMU impact the resistome, not only in the animals but also on the farm environment. Here, we evaluate the resistome footprint of an extensive pig farming system, maintained for decades, as compared to that of industrialized intensive pig farming by analyzing 105 fecal, environmental and slurry metagenomes from 38 farms. Results Our results evidence a significantly higher abundance of antimicrobial resistance genes (ARGs) on intensive farms and a link between AMU and AMR to certain antimicrobial classes. We observed differences in the resistome across sample types, with a higher richness and dispersion of ARGs within environmental samples than on those from feces or slurry. Indeed, a deeper analysis revealed that differences among the three sample types were defined by taxa-ARGs associations. Interestingly, mobilome analyses revealed that the observed AMR differences between intensive and extensive farms could be linked to differences in the abundance of mobile genetic elements (MGEs). Thus, while there were no differences in the abundance of chromosomal-associated ARGs between intensive and extensive herds, a significantly higher abundance of integrons in the environment and plasmids, regardless of the sample type, was detected on intensive farms. Conclusions Overall, this study shows how AMU, production system, and sample type influence, mainly through MGEs, the profile and dispersion of ARGs in pig production. Video Abstracten_US
dc.language.isoenen_US
dc.publisherBiomed Centralen_US
dc.relation.ispartofseriesMicrobiome;
dc.subjectFecesen_US
dc.subjectFarm environmenten_US
dc.subjectMobilomeen_US
dc.subjectOne healthen_US
dc.subjectSustainable farmingen_US
dc.subjectSwineen_US
dc.subjectAntimicrobial resistanceen_US
dc.titleAntimicrobial use and production system shape the fecal, environmental, and slurry resistomes of pig farmsen_US
dc.typeArticleen_US
dc.date.updated2020-11-22T05:31:08Z
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.identifier.doihttps://doi.org/10.1186/s40168-020-00941-7
dc.contributor.sponsorMinisterio de Educación y Formación Profesionalen_US
dc.contributor.sponsorJunta de Castilla y Leónen_US
dc.contributor.sponsorEuropean Social Funden_US
dc.contributor.sponsorEuropean Unionen_US
dc.contributor.sponsorMinistry of Science and Innovation of the Spanish Governmenten_US
dc.contributor.sponsorGrantNumberFPU 16/03485en_US
dc.contributor.sponsorGrantNumberFPU 17/00466en_US
dc.contributor.sponsorGrantNumberLE131-18en_US
dc.contributor.sponsorGrantNumberBEAGAL-18-106en_US
dc.contributor.sponsorGrantNumber818368en_US
dc.contributor.sponsorGrantNumberAGL2016-78085-Pen_US
refterms.dateFOA2021-12-20T17:07:05Z


Files in this item

Thumbnail
Name:
40168_2020_Article_941.pdf
Size:
3.063Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record