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dc.contributor.authorMencía-Ares, Oscar
dc.contributor.authorArgüello, Héctor
dc.contributor.authorPuente, Héctor
dc.contributor.authorGómez-García, Manuel
dc.contributor.authorManzanilla, Edgar G
dc.contributor.authorÁlvarez-Ordóñez, Avelino
dc.contributor.authorCarvajal, Ana
dc.contributor.authorRubio, Pedro
dc.date.accessioned2021-12-22T12:13:26Z
dc.date.available2021-12-22T12:13:26Z
dc.date.issued2021-03-19
dc.identifier.citationMencía-Ares, O., Argüello, H., Puente, H. et al. Antimicrobial resistance in commensal Escherichia coli and Enterococcus spp. is influenced by production system, antimicrobial use, and biosecurity measures on Spanish pig farms. Porc Health Manag 7, 27 (2021). https://doi.org/10.1186/s40813-021-00206-1en_US
dc.identifier.urihttp://hdl.handle.net/11019/2728
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground Antimicrobial resistance (AMR) is a global public health threat consequence of antimicrobial use (AMU) in human and animal medicine. In food-producing animals factors such as management, husbandry or biosecurity may impact AMU. Organic and extensive Iberian swine productions are based on a more sustainable and eco-friendly management system, providing an excellent opportunity to evaluate how sustained differences in AMU impact the AMR in indicator bacteria. Here, we evaluate the usefulness of commensal Escherichia coli and Enterococcus spp. isolates as AMR bioindicators when comparing 37 Spanish pig farms from both intensive and organic-extensive production systems, considering the effect of AMU and biosecurity measures, the last only on intensive farms. Results The production system was the main factor contributing to explain the AMR differences in E. coli and Enterococcus spp. In both bacteria, the pansusceptible phenotype was more common (p < 0.001) on organic-extensive farms when compared to intensive herds. The microbiological resistance in commensal E. coli was, for most of the antimicrobials evaluated, significantly higher (p < 0.05) on intensive farms. In enterococci, the lincosamides usage revealed the association between AMR and AMU, with an increase in the AMR for erythromycin (p < 0.01), quinupristin-dalfopristin (p < 0.01) and the multidrug-resistant (MDR) phenotype (p < 0.05). The biosecurity measures implemented on intensive farms influenced the AMR of these bioindicators, with a slightly lower resistance to sulfamethoxazole (p < 0.01) and the MDR phenotype (p < 0.05) in E. coli isolated from farms with better cleaning and disinfection protocols. On these intensive farms, we also observed that larger herds had a higher biosecurity when compared to smaller farms (p < 0.01), with no significant associations between AMU and the biosecurity scores. Conclusions Overall, this study evidences that the production system and, to a lesser extent, the biosecurity measures, contribute to the AMR development in commensal E. coli and Enterococcus spp., with antimicrobial usage as the main differential factor, and demonstrates the potential value of these bacteria as bioindicators on pig farms in AMR surveillance programs.en_US
dc.language.isoenen_US
dc.publisherBiomed Centralen_US
dc.relation.ispartofseriesPorcine Health Management;
dc.subjectAntibiotic usageen_US
dc.subjectBioindicatoren_US
dc.subjectEnterococcus spp.en_US
dc.subjectEscherichia colien_US
dc.subjectOne healthen_US
dc.subjectSwineen_US
dc.subjectSustainable farmingen_US
dc.titleAntimicrobial resistance in commensal Escherichia coli and Enterococcus spp. is influenced by production system, antimicrobial use, and biosecurity measures on Spanish pig farmsen_US
dc.typeArticleen_US
dc.date.updated2021-03-21T04:26:49Z
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.identifier.doihttps://doi.org/10.1186/s40813-021-00206-1
dc.contributor.sponsorINIAen_US
dc.contributor.sponsorSpanish Government (Ministerio de Educación y Formación Profesional)en_US
dc.contributor.sponsorEuropean Social Funden_US
dc.contributor.sponsor“Beatriz Galindo” Programmeen_US
dc.contributor.sponsorEuropean Unionen_US
dc.contributor.sponsorMinistry of Science and Innovation of the Spanish Governmenten_US
dc.contributor.sponsorGrantNumberRTA2015–00075-c04–03en_US
dc.contributor.sponsorGrantNumberFPU 16/03485en_US
dc.contributor.sponsorGrantNumberFPU 17/00466en_US
dc.contributor.sponsorGrantNumberLE131–18en_US
dc.contributor.sponsorGrantNumberBEAGAL-18-106en_US
dc.contributor.sponsorGrantNumber818368en_US
dc.contributor.sponsorGrantNumberAGL2016–78085-Pen_US
refterms.dateFOA2021-12-22T12:13:27Z


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