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dc.contributor.authorŻarczyńska, Katarzyna
dc.contributor.authorSobiech, Przemysław
dc.contributor.authorTobolski, Dawid
dc.contributor.authorMee, John F
dc.contributor.authorIllek, Josef
dc.date.accessioned2021-12-22T15:44:21Z
dc.date.available2021-12-22T15:44:21Z
dc.date.issued2021-04-23
dc.identifier.citationŻarczyńska, K., Sobiech, P., Tobolski, D. et al. Effect of a single, oral administration of selenitetriglycerides, at two dose rates, on blood selenium status and haematological and biochemical parameters in Holstein-Friesian calves. Ir Vet J 74, 11 (2021). https://doi.org/10.1186/s13620-021-00192-4en_US
dc.identifier.urihttp://hdl.handle.net/11019/2743
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground Selenitetriglycerides are biologically active, organic forms of selenium formed as a result of the modification of selenic acid and sunflower oil. Studies in rats have shown that they are well absorbed and of low toxicity. There are no published studies on selenitetriglycerides supplementation in calves. Results In this study, selenitetriglycerides were administered once orally on the 2nd day of life at a dose of 0.5 or 1 mg Se/kg body weight to each of six Holstein-Friesian calves while six control calves were not supplemented. Blood for determination of selenium concentration, glutathione peroxidase activity, haematological parameters, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase activities and glucose, total protein, albumin, triglycerides, cholesterol, urea, and creatinine concentration was collected before supplementation (day 0) and 1, 2, 5, 10 and 14 days after supplementation. Selenitetriglycerides administration increased (P < 0.01) serum selenium concentration in supplemented calves as early as day1, from a mean of 63.4 to 184.22 µg/l in calves receiving selenium at a dose of 0.5 mg/kg BW, and from 63.17 to 200.33 µg/l in calves receiving 1 mg/kg. Serum selenium concentrations remained significantly higher compared to the control group throughout the experiment. Glutathione peroxidase activity was higher in supplemented than control calves, significantly so in animals receiving the 1 mg/kg dose of Se on the 10th and 14th days (P < 0.05). There were no significant differences in the haematological and biochemical parameters between the groups. Conclusions This experiment showed that supplementation with selenitetriglycerides could significantly improve blood selenium status in calves without adverse effects on haematological or biochemical parameters. These findings are essential prerequisites for future studies on selenitetriglycerides supplementation to manage clinical selenium deficiency in calves.en_US
dc.language.isoenen_US
dc.publisherBiomed Centralen_US
dc.relation.ispartofseriesIrish Veterinary Journal;
dc.subjectSeleniumen_US
dc.subjectSelenitetriglyceridesen_US
dc.subjectCalvesen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectBiochemical parametersen_US
dc.subjectHaematologyen_US
dc.titleEffect of a single, oral administration of selenitetriglycerides, at two dose rates, on blood selenium status and haematological and biochemical parameters in Holstein-Friesian calvesen_US
dc.typeArticleen_US
dc.date.updated2021-04-26T07:58:05Z
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.identifier.doihttps://doi.org/10.1186/s13620-021-00192-4
dc.contributor.sponsorUniversity of Warmia and Mazuryen_US
dc.contributor.sponsorMinister of Science and Higher Education, Polanden_US
dc.contributor.sponsorGrantNumber010/RID/2018/19en_US
refterms.dateFOA2021-12-22T15:44:21Z


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