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dc.contributor.authorSchellekens, Harriët
dc.contributor.authorTorres-Fuentes, Cristina
dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorLong-Smith, Caitriona M.
dc.contributor.authorMitchell, Avery
dc.contributor.authorStrain, Conall
dc.contributor.authorBerding, Kirsten
dc.contributor.authorBastiaanssen, Thomaz, F. S.
dc.contributor.authorRea, Kieran
dc.contributor.authorGolubeva, Anna V.
dc.contributor.authorArboyela, Silvia
dc.contributor.authorVerpaalen, Mathieu
dc.contributor.authorPusceddu, Matteo M.
dc.contributor.authorMurphy, Amy
dc.contributor.authorFouhy, Fiona
dc.contributor.authorMurphy, Kiera
dc.contributor.authorRoss, Paul
dc.contributor.authorRoy, Bernard L.
dc.contributor.authorSTANTON, CATHERINE
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.date.accessioned2022-08-30T11:37:57Z
dc.date.available2022-08-30T11:37:57Z
dc.date.issued2021-01-31
dc.identifier.citationHarriët Schellekens, Cristina Torres-Fuentes, Marcel van de Wouw, Caitriona M. Long-Smith, Avery Mitchell, Conall Strain, Kirsten Berding, Thomaz F.S. Bastiaanssen, Kieran Rea, Anna V. Golubeva, Silvia Arboleya, Mathieu Verpaalen, Matteo M. Pusceddu, Amy Murphy, Fiona Fouhy, Kiera Murphy, Paul Ross, Bernard L. Roy, Catherine Stanton, Timothy G. Dinan, John F. Cryan, Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human, EBioMedicine, 2021, 63, 103176, DOI: https://doi.org/10.1016/j.ebiom.2020.103176en_US
dc.identifier.issn23523964
dc.identifier.urihttp://hdl.handle.net/11019/2835
dc.descriptionpeer-revieweden_US
dc.description.abstractBackgroundThe human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes. MethodsB. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention. FindingsB. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]). InterpretationThis study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity. FundingThis research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesEBioMedicine;
dc.rights© 2020 The Authors. Published by Elsevier B.V.
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectObesityen_US
dc.subjectTranslationalen_US
dc.subjectFasting blood glucoseen_US
dc.subjectGhrelinen_US
dc.subjectCortisolen_US
dc.subjectGut microbiotaen_US
dc.subjectProbioticen_US
dc.subjectBifidobacterium longumen_US
dc.titleBifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to humanen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.ebiom.2020.103176
dc.identifier.eid1-s2.0-S2352396420305521
dc.identifier.piiS2352-3964(20)30552-1
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.source.volume63
dc.source.beginpage103176
refterms.dateFOA2022-08-30T11:37:58Z
dc.source.journaltitleEBioMedicine
dc.identifier.journalEBioMedicine


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© 2020 The Authors. Published by Elsevier B.V.
Except where otherwise noted, this item's license is described as © 2020 The Authors. Published by Elsevier B.V.