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dc.contributor.authorQuinn, Erin M.
dc.contributor.authorF. O'Callaghan, Tom
dc.contributor.authorT. Tobin, John
dc.contributor.authorMurphy, John Paul
dc.contributor.authorSugrue, Katie
dc.contributor.authorSlattery, Helen
dc.contributor.authorO'Donovan, Michael
dc.contributor.authorHickey, Rita M.
dc.date.accessioned2022-09-08T14:30:37Z
dc.date.available2022-09-08T14:30:37Z
dc.date.issued2020-12-01
dc.identifier.citationQuinn, E.M.; O’Callaghan, T.F.; Tobin, J.T.; Murphy, J.P.; Sugrue, K.; Slattery, H.; O’Donovan, M.; Hickey, R.M. Changes to the Oligosaccharide Profile of Bovine Milk at the Onset of Lactation. Dairy 2020, 1, 284-296. https://doi.org/10.3390/dairy1030019en_US
dc.identifier.urihttp://hdl.handle.net/11019/2842
dc.descriptionpeer-revieweden_US
dc.description.abstractNumerous bioactive components exist in human milk including free oligosaccharides, which represent some of the most important, and provide numerous health benefits to the neonate. Considering the demonstrated value of these compounds, much interest lies in characterising structurally similar oligosaccharides in the dairy industry. In this study, the impacts of days post-parturition and parity of the cows on the oligosaccharide and lactose profiles of their milk were evaluated. Colostrum and milk samples were obtained from 18 cows 1–5 days after parturition. Three distinct phases were identified using multivariate analysis: colostrum (day 0), transitional milk (days 1–2) and mature milk (days 3–5). LS-tetrasaccharide c, lacto-N-neotetraose, disialyllacto-N-tetraose, 3’-sial-N-acetyllactosamine, 3’-sialyllactose, lacto-N-neohexaose and disialyllactose were found to be highly affiliated with colostrum. Notably, levels of lactose were at their lowest concentration in the colostrum and substantially increased 1-day post-parturition. The cow’s parity was also shown to have a significant effect on the oligosaccharide profile, with first lactation cows containing more disialyllacto-N-tetraose, 6’-sialyllactose and LS-tetrasaccharide compared to cows in their second or third parity. Overall, this study identifies key changes in oligosaccharide and lactose content that clearly distinguish colostrum from transitional and mature milk and may facilitate the collection of specific streams with divergent biological functions.en_US
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.relation.ispartofseriesDairy;Vol 1
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbovine milk oligosaccharidesen_US
dc.subjectlactationen_US
dc.subjectparityen_US
dc.subjectprofilesen_US
dc.subjectphasesen_US
dc.titleChanges to the Oligosaccharide Profile of Bovine Milk at the Onset of Lactationen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/dairy1030019
dc.contributor.sponsorTeagascen_US
refterms.dateFOA2022-09-08T14:30:38Z


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