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dc.contributor.authorYebra, Gonzalo
dc.contributor.authorHarling-Lee, Joshua D.
dc.contributor.authorLycett, Samantha
dc.contributor.authorAarestrup, Frank M.
dc.contributor.authorLarsen, Gunhild
dc.contributor.authorCavaco, Lina M.
dc.contributor.authorSeo, Keun Seok
dc.contributor.authorAbraham, Sam
dc.contributor.authorNorris, Jacqueline M.
dc.contributor.authorSchmidt, Tracy
dc.contributor.authorEhlers, Marthie M.
dc.contributor.authorSordelli, Daniel O.
dc.contributor.authorBuzzola, Fernanda R.
dc.contributor.authorGebreyes, Wondwossen A.
dc.contributor.authorGonçalves, Juliano L.
dc.contributor.authordos Santos, Marcos V.
dc.contributor.authorZakaria, Zunita
dc.contributor.authorRall, Vera L. M.
dc.contributor.authorKeane, Orla
dc.contributor.authorNiedziela, Dagmara A.
dc.contributor.authorPaterson, Gavin K.
dc.contributor.authorHolmes, Mark A.
dc.contributor.authorFreeman, Tom C.
dc.contributor.authorFitzgerald, J. Ross
dc.date.accessioned2023-01-11T17:14:17Z
dc.date.available2023-01-11T17:14:17Z
dc.date.issued2022-12-05
dc.identifier.citationYebra G, Harling-Lee JD, Lycett S, Aarestrup FM, Larsen G, Cavaco LM, Seo KS, Abraham S, Norris JM, Schmidt T and others. Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock. Proceedings of the National Academy of Sciences of the United States of America 2022;119(50); doi http://dx.doi.org/10.1073/pnas.2211217119en_US
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11019/2887
dc.descriptionpeer-revieweden_US
dc.description.abstractMost new pathogens of humans and animals arise via switching events from distinct host species. However, our understanding of the evolutionary and ecological drivers of successful host adaptation, expansion, and dissemination are limited. Staphylococcus aureus is a major bacterial pathogen of humans and a leading cause of mastitis in dairy cows worldwide. Here we trace the evolutionary history of bovine S. aureus using a global dataset of 10,254 S. aureus genomes including 1,896 bovine isolates from 32 countries in 6 continents. We identified 7 major contemporary endemic clones of S. aureus causing bovine mastitis around the world and traced them back to 4 independent host-jump events from humans that occurred up to 2,500 y ago. Individual clones emerged and underwent clonal expansion from the mid-19th to late 20th century coinciding with the commercialization and industrialization of dairy farming, and older lineages have become globally distributed via established cattle trade links. Importantly, we identified lineage-dependent differences in the frequency of host transmission events between humans and cows in both directions revealing high risk clones threatening veterinary and human health. Finally, pangenome network analysis revealed that some bovine S. aureus lineages contained distinct sets of bovine-associated genes, consistent with multiple trajectories to host adaptation via gene acquisition. Taken together, we have dissected the evolutionary history of a major endemic pathogen of livestock providing a comprehensive temporal, geographic, and gene-level perspective of its remarkable success.en_US
dc.description.sponsorshipWellcome Trust
dc.language.isoenen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.ispartofseriesProceedings of the National Academy of Sciences of the United States of America;
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectStaphylococcus aureusen_US
dc.subjectpopulation genomicsen_US
dc.subjectphylodynamicsen_US
dc.subjectAgricultureen_US
dc.subjecthost adaptationen_US
dc.titleMulticlonal human origin and global expansion of an endemic bacterial pathogen of livestocken_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.2211217119
dc.identifier.pii10.1073/pnas.2211217119
dc.source.volume119
dc.source.issue50
refterms.dateFOA2023-01-11T17:14:18Z
dc.source.journaltitleProceedings of the National Academy of Sciences
dc.identifier.eissn1091-6490


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