Show simple item record

dc.contributor.authorMesa-Pereira, Beatriz
dc.contributor.authorRea, Mary C.
dc.contributor.authorCotter, Paul D.
dc.contributor.authorHill, Colin
dc.contributor.authorRoss, R. Paul
dc.date.accessioned2023-06-28T10:53:56Z
dc.date.available2023-06-28T10:53:56Z
dc.date.issued2018-07-26
dc.identifier.citationMesa-Pereira B, Rea MC, Cotter PD, Hill C and Ross RP (2018) Heterologous Expression of Biopreservative Bacteriocins With a View to Low Cost Production. Front. Microbiol. 9:1654. doi: 10.3389/fmicb.2018.01654en_US
dc.identifier.urihttp://hdl.handle.net/11019/2961
dc.descriptionpeer-revieweden_US
dc.description.abstractBacteriocins, a heterogenous group of antibacterial ribosomally synthesized peptides, have potential as bio-preservatives in in a wide range of foods and as future therapeutics for the inhibition of antibiotic-resistant bacteria. While many bacteriocins have been characterized, several factors limit their production in large quantities, a requirement to make them commercially viable for food or pharma applications. The identification of new bacteriocins by database mining has been promising, but their potential is difficult to evaluate in the absence of suitable expression systems. E. coli has been used as a heterologous host to produce recombinant proteins for decades and has an extensive set of expression vectors and strains available. Here, we review the different expression systems for bacteriocin production using this host and identify the most important features to guarantee successful production of a range of bacteriocins.en_US
dc.description.sponsorshipScience Foundation Ireland
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofseriesFrontiers in Microbiology;Vol 9
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbacteriocinsen_US
dc.subjectheterologous expressionen_US
dc.subjectE. colien_US
dc.subjectvectorsen_US
dc.subjectstrainsen_US
dc.titleHeterologous Expression of Biopreservative Bacteriocins With a View to Low Cost Productionen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3389/fmicb.2018.01654
dc.contributor.sponsorScience Foundation Ireland (SFI)en_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.source.volume9
refterms.dateFOA2023-06-28T10:53:58Z
dc.source.journaltitleFrontiers in Microbiology


Files in this item

Thumbnail
Name:
fmicb-09-01654.pdf
Size:
1.043Mb
Format:
PDF
Description:
main article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International