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dc.contributor.authorO’Hara, Eóin
dc.contributor.authorKelly, Alan
dc.contributor.authorMcCabe, Matthew S.
dc.contributor.authorKenny, David A.
dc.contributor.authorGuan, Le Luo
dc.contributor.authorWaters, Sinéad M.
dc.date.accessioned2023-06-29T11:46:08Z
dc.date.available2023-06-29T11:46:08Z
dc.date.issued2018-10-08
dc.identifier.citationO’Hara, E., Kelly, A., McCabe, M.S. et al. Effect of a butyrate-fortified milk replacer on gastrointestinal microbiota and products of fermentation in artificially reared dairy calves at weaning. Sci Rep 8, 14901 (2018). https://doi.org/10.1038/s41598-018-33122-6en_US
dc.identifier.urihttp://hdl.handle.net/11019/2970
dc.descriptionpeer-revieweden_US
dc.description.abstractEnrichment of calf diets with exogenous butyrate has shown promise as a promotor of calf growth and intestinal development. However, the impact of dietary derived butyrate on the gut microbiota and their potential role, in turn, as mediators of its effect on calf growth and development is not known. Here, the effects of butyrate supplementation on rumen and hindgut microbiota and fermentation profiles were assessed in 16 Holstein-Friesian bull calves randomly assigned to one of two groups: Control (CON) fed conventional milk replacer or Sodium-Butyrate (SB – added to milk replacer) from days 7 to 56 of life. In the colon, total short chain fatty acid (SCFA), propionate and acetate concentrations were increased by SB (P < 0.05). 16S rRNA gene amplicon sequencing showed cecal abundance of butyrate producers Butyrivibrio and Shuttleworthia were decreased by SB (P < 0.05), while that of the propionate producer Phascolarctobacterium was higher (P < 0.05). Mogibacterium is associated with impaired gut health and was reduced in the cecum of SB calves (P < 0.05). These data show that the beneficial effects of SB on growth and performance occur in tandem with changes in the abundance of important SCFA producing and health-associated bacteria in the hindgut in milk-fed calves.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesScientific Reports;Vol 8
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectMilk Replaceren_US
dc.subjectDairy Calvesen_US
dc.subjectHindgut Microbiotaen_US
dc.subjectButyrate Supplementationen_US
dc.subjectTotal SCFAen_US
dc.titleEffect of a butyrate-fortified milk replacer on gastrointestinal microbiota and products of fermentation in artificially reared dairy calves at weaningen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1038/s41598-018-33122-6
dc.contributor.sponsorTeagascen_US
dc.contributor.sponsorTeagasc Walsh Fellowshipen_US
dc.contributor.sponsorGrantNumber6341en_US
dc.contributor.sponsorGrantNumberWF 2013047en_US
dc.source.volume8
dc.source.issue1
refterms.dateFOA2023-06-29T11:46:09Z
dc.source.journaltitleScientific Reports


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