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dc.contributor.authorHorodyska, Justyna
dc.contributor.authorHamill, Ruth M.
dc.contributor.authorReyer, Henry
dc.contributor.authorTrakooljul, Nares
dc.contributor.authorLawlor, Peadar G.
dc.contributor.authorMcCormack, Ursula M.
dc.contributor.authorWimmers, Klaus
dc.identifier.citationHorodyska J, Hamill RM, Reyer H, Trakooljul N, Lawlor PG, McCormack UM and Wimmers K (2019) RNA-Seq of Liver From Pigs Divergent in Feed Efficiency Highlights Shifts in Macronutrient Metabolism, Hepatic Growth and Immune Response. Front. Genet. 10:117. doi: 10.3389/fgene.2019.00117en_US
dc.description.abstractLiver is a metabolically complex organ that influences nutrient partitioning and potentially modulates the efficiency of converting energy acquired from macronutrients ingestion into a muscle and/or adipose tissue (referred to as feed efficiency, FE). The objective of this study was to sequence the hepatic tissue transcriptome of closely related but differently feed efficient pigs (n = 16) and identify relevant biological processes that underpin the differences in liver phenotype between FE groups. Liver weight did not significantly differ between the FE groups, however, blood parameters showed that total protein, glucose, cholesterol and percentage of lymphocytes were significantly greater in high-FE pigs. Ontology analysis revealed carbohydrate, lipid and protein metabolism to be significantly enriched with differentially expressed genes. In particular, high-FE pigs exhibited gene expression patterns suggesting improved absorption of carbohydrates and cholesterol as well as enhanced reverse cholesterol transport. Furthermore, the inferred decrease in bile acid synthesis in high-FE pigs may contribute to the observed greater levels of serum glucose, which can be then delivered to cells and utilized for growth and maintenance. Gene ontology analysis also suggested that livers of more efficient pigs may be characterized by higher protein turnover and increased epithelial cell differentiation, whereby an enhanced quantity of invariant natural killer T-cells and viability of natural killer cells could induce a quicker and more effective hepatic response to inflammatory stimuli. Our findings suggest that this prompt hepatic response to inflammation in high-FE group may contribute to the more efficient utilization of nutrients for growth in these animals.en_US
dc.description.sponsorshipSeventh Framework Programme
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofseriesFrontiers in Genetics;Vol 10
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.subjectresidual feed intakeen_US
dc.subjectgene expressionen_US
dc.titleRNA-Seq of Liver From Pigs Divergent in Feed Efficiency Highlights Shifts in Macronutrient Metabolism, Hepatic Growth and Immune Responseen_US
dc.contributor.sponsorEuropean Union Seventh Framework Programmeen_US
dc.source.journaltitleFrontiers in Genetics

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