Variation in the proportion of the segregating genome shared between full-sibling cattle and sheep
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CitationKenny, D., Berry, D.P., Pabiou, T. et al. Variation in the proportion of the segregating genome shared between full-sibling cattle and sheep. Genet Sel Evol 55, 27 (2023). https://doi.org/10.1186/s12711-023-00802-5
AbstractThe construction of covariance matrices that account for the genetic relationships among individuals, using pedigree or genotype data, is integral to genetic evaluations, which are now routinely used in the field of animal breeding. The objective of the present study was to estimate the standard deviation in the proportion of the segregating genome that is shared between pairs of full-sibling cattle and sheep independently. Post edits, genotype data comprising 46,069 autosomal single nucleotide polymorphisms (SNPs) were available for 4532 unique full-sibling sheep pairs, as well as for their respective parents. Post edits, genotypes from 50,493 autosomal SNPs were also available for 10,000 unique full-sibling cattle pairs, as well as their respective parents. Genomic relationship matrices were constructed for the sheep and cattle populations, separately. After accounting for both parental genomic inbreeding and the genomic relationship between both parents, the standard deviation in full-sibling cattle and sheep genomic relationships was 0.040 and 0.037 units, respectively. In addition, the intercept value from a linear regression model which regressed each full-sibling genomic relationship on both sire and dam inbreeding, as well as the genomic relationship between the parents, was 0.499 (0.001) for sheep and 0.500 (0.001) for cattle, conforming to the expectation that full-siblings, on average, share 50% of their segregating genome.
FunderEuropean Union Horizon 2020; Science Foundation Ireland
Grant NumberGenTore 727213; INTAQT 101000250; 16/RC/3835