Detection of Genomic Imprinting for Carcass Traits in Cattle Using Imputed High-Density Genotype Data.
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CitationKenny D, Sleator RD, Murphy CP, Evans RD, Berry DP. Detection of Genomic Imprinting for Carcass Traits in Cattle Using Imputed High-Density Genotype Data. Front Genet. 2022 Jul 15;13:951087. doi: 10.3389/fgene.2022.951087. PMID: 35910233; PMCID: PMC9334527.
AbstractGenomic imprinting is an epigenetic phenomenon defined as the silencing of an allele, at least partially, at a given locus based on the sex of the transmitting parent. The objective of the present study was to detect the presence of SNP-phenotype imprinting associations for carcass weight (CW), carcass conformation (CC) and carcass fat (CF) in cattle. The data used comprised carcass data, along with imputed, high-density genotype data on 618,837 single nucleotide polymorphisms (SNPs) from 23,687 cattle; all animal genotypes were phased with respect to parent of origin. Based on the phased genotypes and a series of single-locus linear models, 24, 339, and 316 SNPs demonstrated imprinting associations with CW, CC, and CF, respectively. Regardless of the trait in question, no known imprinted gene was located within 0.5 Mb of the SNPs demonstrating imprinting associations in the present study. Since all imprinting associations detected herein were at novel loci, further investigation of these regions may be warranted. Nonetheless, knowledge of these associations might be useful for improving the accuracy of genomic evaluations for these traits, as well as mate allocations systems to exploit the effects of genomic imprinting.
FunderDepartment of Agriculture, Food and the Marine; Science Foundation Ireland
Grant NumberRSF 17/S/235; 16/RC/3835; VistaMilk
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Except where otherwise noted, this item's license is described as Copyright © 2022 Kenny, Sleator, Murphy, Evans and Berry.