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CitationCarthy, T.R.; Keane, O.M.; Hanrahan, J.P.; Matthews, D.; McEwan, J.; Rowe, S. and Mee, J. (2022). Investigation of Intestinal Atresia in a Jersey Sire Family, Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP), pp2810 - 2813
AbstractIntestinal atresia is a congenital defect resulting in calf mortality within a few days of birth. This study focuses on two half-sibling Jersey sires who were identified as having a high proportion of their progeny exhibiting atresia from a longitudinal study of 39 dairy herds over an 8 year period. The objective of this study was to investigate the genetic cause of intestinal atresia within this family. Phased high-density genotypes of the two half-sibling sires were used to identify if common haplotypes were inherited by all affected animals. Whether or not the paternal haplotype that was inherited by the affected animal at a given locus deviated from the expectation was tested. A total of 16 SNPs were significantly overrepresented, 14 located in one region on chromosome 14 and the remaining 2 located in one region on chromosome 26.
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