• Login
    View Item 
    •   T-Stór
    • Animal & Grassland Research & Innovation Programme
    • Animal & Bioscience
    • View Item
    •   T-Stór
    • Animal & Grassland Research & Innovation Programme
    • Animal & Bioscience
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of T-StórCommunitiesPublication DateAuthorsTitlesSubjectsFunderThis CollectionPublication DateAuthorsTitlesSubjectsFunderProfilesView

    My Account

    LoginRegister

    Information

    Deposit AgreementLicense

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Single nucleotide polymorphisms in the insulin-like growth factor 1 (IGF-1) gene are associated with performance in Holstein-Friesian dairy cattle

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    mullen_etal2011_IGF1_SNPs.pdf
    Size:
    343.7Kb
    Format:
    PDF
    Download
    Author
    Mullen, Michael P.
    Berry, Donagh cc
    Howard, Dawn J.
    Diskin, Michael G.
    Lynch, Ciaran Oliver
    Giblin, Linda cc
    Kenny, David A.
    Magee, David A
    Meade, Kieran G
    Waters, Sinead M.
    Keyword
    single nucleotide polymorphism
    Performance
    Holstein-Friesian dairy cattle
    Date
    16/02/2011
    
    Metadata
    Show full item record
    Statistics
    Display Item Statistics
    URI
    http://hdl.handle.net/11019/351
    Citation
    Mullen, M.P., Berry, D.P., Howard, D., Diskin, M.G., Lynch, C.O., Giblin, L., Kenny, D.A., Magee, D.A., Meade, K. and Waters, S. (2011). Single nucleotide polymorphisms in the insulin-like growth factor 1 (IGF-1) gene are associated with performance in Holstein-Friesian dairy cattle. Frontiers in Genetics 2: 3, 1-9. DOI: 10.3389/fgene.2011.00003
    Abstract
    Insulin-like growth factor 1 (IGF-1) has been shown to be associated with fertility, growth, and development in cattle. The aim of this study was to (1) identify novel single nucleotide polymorphisms (SNPs) in the bovine IGF-1 gene and alongside previously identified SNPs (2) determine their association with traits of economic importance in Holstein-Friesian dairy cattle. Nine novel SNPs were identified across a panel of 22 beef and dairy cattle by sequence analysis of the 5′ promoter, intronic, and 3′ regulatory regions, encompassing ∼5 kb of IGF-1. Genotyping and associations with daughter performance for milk production, fertility, survival, and measures of body size were undertaken on 848 Holstein-Friesian AI sires. Using multiple regression analysis nominal associations (P < 0.05) were identified between six SNPs (four novel and two previously identified) and milk composition, survival, body condition score, and body size. The C allele of AF017143 a previously published SNP (C-512T) in the promoter region of IGF-1 predicted to introduce binding sites for transcription factors HSF1 and ZNF217 was associated (P < 0.05) with increased cow carcass weight (i.e., an indicator of mature cow size). Novel SNPs were identified in the 3′ region of IGF-1 were associated (P < 0.05) with functional survival and chest width. The remaining four SNPs, all located within introns of IGF-1 were associated (P < 0.05) with milk protein yield, milk fat yield, milk fat concentration, somatic cell score, carcass conformation, and carcass fat. Results of this study further demonstrate the multifaceted influences of IGF-1 on milk production and growth related traits in cattle.
    Funder
    Science Foundation Ireland; Department of Agriculture, Food and the Marine
    Grant Number
    07/SRC/B1156; RSF-06-0353; RSF-06-0409; Irish Dairy Levy Research Trust
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.3389/fgene.2011.00003
    Scopus Count
    Collections
    Food Biosciences
    Animal & Bioscience
    Animal & Bioscience
    Animal & Bioscience

    entitlement

     
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.