Infant milk formula, produced by membrane filtration, promotes mucus production in the upper small intestine of young pigs
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Author
Dold, Cathal A.Bavaro, Simona L.
Chen, Yihong
Callanan, Michael J.
Kennedy, Deirdre
Cassidy, Joe
Tobin, John
Sahin, Aylin W.
Lawlor, Peadar G.
Brodkorb, André
Giblin, Linda
Date
2024-07
Metadata
Show full item recordStatistics
Display Item StatisticsCitation
Cathal A. Dold, Simona L. Bavaro, Yihong Chen, Michael J. Callanan, Deirdre Kennedy, Joe Cassidy, John Tobin, Aylin W. Sahin, Peadar G. Lawlor, André Brodkorb, Linda Giblin, Infant milk formula, produced by membrane filtration, promotes mucus production in the upper small intestine of young pigs, Food Research International, Volume 187, 2024, 114343, https://doi.org/10.1016/j.foodres.2024.114343.Abstract
Human breast milk promotes maturation of the infant gastrointestinal barrier, including the promotion of mucus production. In the quest to produce next generation infant milk formula (IMF), we have produced IMF by membrane filtration (MEM-IMF). With a higher quantity of native whey protein, MEM-IMF more closely mimics human breast milk than IMF produced using conventional heat treatment (HT-IMF). After a 4-week dietary intervention in young pigs, animals fed a MEM-IMF diet had a higher number of goblet cells, acidic mucus and mucin-2 in the jejunum compared to pigs fed HT-IMF (P < 0.05). In the duodenum, MEM-IMF fed pigs had increased trypsin activity in the gut lumen, increased mRNA transcript levels of claudin 1 in the mucosal scrapings and increased lactase activity in brush border membrane vesicles than those pigs fed HT-IMF (P < 0.05). In conclusion, MEM-IMF is superior to HT-IMF in the promotion of mucus production in the young gut.Funder
Science Foundation Ireland (SFI); Department of Agriculture, Food, and the Marine; Teagasc Walsh ScholarshipGrant Number
16/RC/3835ae974a485f413a2113503eed53cd6c53
10.1016/j.foodres.2024.114343
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons