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dc.contributor.authorDold, Cathal A.
dc.contributor.authorSahin, Aylin W.
dc.contributor.authorGiblin, Linda
dc.date.accessioned2025-01-28T15:56:23Z
dc.date.available2025-01-28T15:56:23Z
dc.date.issued2024-12
dc.identifier.citationCathal A. Dold, Aylin W. Sahin, Linda Giblin, Effect of processing infant milk formula on protein digestion and gut barrier health (in vitro and preclinical), Journal of Dairy Science, 2024, , ISSN 0022-0302, https://doi.org/10.3168/jds.2024-25356.en_US
dc.identifier.issn0022-0302
dc.identifier.urihttp://hdl.handle.net/11019/3755
dc.descriptionPeer-revieweden_US
dc.description.abstractThe infant gut is immature and permeable with high gastric pH, low protease activities and underdeveloped intestinal architecture. Protein digestion in the upper gastrointestinal tract of infants is slow and incomplete. During manufacture, infant milk formula (IMF) is typically heat-treated so it is safe for human consumption. This heat treatment causes denaturation and aggregation of milk proteins, and formation of undesirable Maillard reaction products. The aim of this review is to critically summarize the in vitro and preclinical data available on the effect of IMF thermal processing on protein digestion and gut barrier physiology in the immature infant gut. Recent research efforts have focused on reducing thermal loads during IMF manufacturing by sourcing ingredients with low thermal loads, by reducing temperatures during IMF processing itself and by seeking alternative processing technologies. This review also aims to evaluate if these thermal reductions have a knock-on effect on protein digestion and gut barrier health in the infant. The ultimate aim is to create a safe next generation IMF product that more closely mimics human breast milk in its protein digestion kinetics and its ability to promote gut barrier maturity in the infant.en_US
dc.language.isoenen_US
dc.publisherAmerican Dairy Science Associationen_US
dc.relation.ispartofseriesJournal of Dairy Science;
dc.rights© 2024
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectInfant milk formulaen_US
dc.subjectProcessingen_US
dc.subjectProtein digestionen_US
dc.subjectGut barrier healthen_US
dc.subjectInfanten_US
dc.titleEffect of processing infant milk formula on protein digestion and gut barrier health (in vitro and preclinical)en_US
dc.typeArticleen_US
dc.identifier.doi10.3168/jds.2024-25356
dc.identifier.doihttps://doi.org/10.3168/jds.2024-25356
dc.identifier.piiS0022030224012372
dc.contributor.sponsorScience Foundation Ireland (SFI)en_US
dc.contributor.sponsorDepartment of Agriculture, Food, and the Marineen_US
dc.contributor.sponsorTeagasc Walsh Scholarshipen_US
dc.contributor.sponsorGrantNumber16/RC/3835en_US
refterms.dateFOA2025-01-28T15:56:25Z
dc.source.journaltitleJournal of Dairy Science


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