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dc.contributor.authorBerkowicz, Erik W*
dc.contributor.authorMagee, David A*
dc.contributor.authorSikora, Klaudia M*
dc.contributor.authorBerry, Donagh*
dc.contributor.authorHoward, Dawn J.*
dc.contributor.authorMullen, Michael P.*
dc.contributor.authorEvans, R. D.*
dc.contributor.authorSpillane, Charles*
dc.contributor.authorMacHugh, David E*
dc.date.accessioned2013-04-24T15:54:57Z
dc.date.available2013-04-24T15:54:57Z
dc.date.issued2010-09
dc.identifier.citationErik W Berkowicz, David A Magee, Klaudia M Sikora, Donagh P Berry, Dawn J Howard, Michael P Mullen, Ross D Evans, Charles Spillane and David E MacHugh (2011). Single nucleotide polymorphisms at the imprinted bovine insulin-like growth factor 2 (IGF2) locus are associated with dairy performance in Irish Holstein-Friesian cattle. Journal of Dairy Research, 78, pp 1-8. doi:10.1017/S0022029910000567. Copyright © Proprietors of Journal of Dairy Researchen_GB
dc.identifier.issn1469-7629
dc.identifier.urihttp://hdl.handle.net/11019/377
dc.identifier.urihttp://dx.doi.org/10.1017/S0022029910000567
dc.identifier.urihttp://journals.cambridge.org/article_S0022029910000567
dc.descriptionpeer-revieweden_GB
dc.description.abstractThe imprinted insulin-like growth factor 2 gene (IGF2) encodes a fetal mitogenic hormone protein (IGF-II) and has previously been shown to be associated with performance in dairy cattle. In this study we assessed genotype-phenotype associations between four single nucleotide polymorphisms (SNPs) located within the bovine IGF2 locus on chromosome 29 and a range of performance traits related to milk production, animal growth and body size, fertility and progeny survival in 848 progeny-tested Irish Holstein-Friesian sires. Two of the four SNPs (rs42196909 and IGF2.g-3815A>G), which were in strong linkage disequilibrium (r 2=0.995), were associated with milk yield (Pf0.01) and milk protein yield (Pf0.05); the rs42196901 SNP was also associated (Pf0.05) with milk fat yield. Associations (Pf0.05) with milk fat percentage and milk protein percentage were observed at the rs42196901 and IGF2.g-3815A>G SNPs, respectively. The rs42196909 and IGF2.g-3815A>G SNPs were also associated with progeny carcass conformation (Pf0.05), while an association (Pf0.01) with progeny carcass weight was observed at the rs42194733 SNP locus. None of the four SNPs were associated with body size, fertility and progeny survival. These findings support previous work which suggests that the IGF2 locus is an important biological regulator of milk production in dairy cattle and add to an accumulating body of research showing that imprinted genes influence many complex performance traits in cattle.en_GB
dc.description.sponsorshipThis work was supported by a Research Stimulus Grant from the Irish Department of Agriculture, Fisheries and Food (project number: RSF-06-0406, RSF-06-0353; RSF-06-0409) and Investigator Programme Grants from Science Foundation Ireland (SFI/01/F.1/B028 and SFI/08/IN.l/B2038). MPM was funded by Science Foundation Ireland research grant number 07/SRC/B1156.en_GB
dc.language.isoenen_GB
dc.publisherCambridge University Press: Published for the Institute of Food Research and the Hannah Research Instituteen_GB
dc.relation.ispartofseriesJournal of Dairy Research;vol 78
dc.subjectBosen_GB
dc.subjectCattleen_GB
dc.subjectGenetic imprintingen_GB
dc.subjectIGF2en_GB
dc.subjectPerformance traitsen_GB
dc.subjectSingle nucleotide polymorphismen_GB
dc.titleSingle nucleotide polymorphisms at the imprinted bovine insulin-like growth factor 2 (IGF2) locus are associated with dairy performance in Irish Holstein-Friesian cattleen_GB
dc.typeArticleen_GB
dc.identifier.rmisMKAB-0201-5666
refterms.dateFOA2018-01-12T07:58:19Z
dc.relation.isnodouble367*


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