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dc.contributor.authorBerry, Donagh*
dc.contributor.authorMeade, Kieran G*
dc.contributor.authorMullen, Michael P.*
dc.contributor.authorButler, Stephen T.*
dc.contributor.authorDiskin, Michael G.*
dc.contributor.authorMorris, Dermot G.*
dc.contributor.authorCreevey, Christopher J.*
dc.date.accessioned2013-04-24T16:08:38Z
dc.date.available2013-04-24T16:08:38Z
dc.date.issued2010-10
dc.identifier.citationD. P. Berry, K. G. Meade, M. P. Mullen, S. Butler, M. G. Diskin, D. Morris and C. J. Creevey (2011). The integration of ‘omic’ disciplines and systems biology in cattle breeding. animal, 5, pp 493-505. doi:10.1017/S1751731110002120en_GB
dc.identifier.issn1751-732X
dc.identifier.urihttp://hdl.handle.net/11019/379
dc.descriptionpeer-revieweden_GB
dc.description.abstractEnormous progress has been made in the selection of animals, including cattle, for specific traits using traditional quantitative genetics approaches. Never the less, considerable variation in phenotypes remains unexplained, and therefore represents potential additional gain for animal production. In addition, the paradigm shift in new disciplines now being applied to animal breeding represents a powerful opportunity to prise open the ‘black box’ underlying the response to selection and fully understand the genetic architecture controlling the traits of interest. A move away from traditional approaches of animal breeding toward systems approaches using integrative analysis of data from the ‘omic’ disciplines represents a multitude of exciting opportunities for animal breeding going forward as well as providing alternatives for overcoming some of the limitations of traditional approaches such as the expressed phenotype being an imperfect predictor of the individual’s true genetic merit, or the phenotype being only expressed in one gender or late in the lifetime of an animal. This review aims to discuss these opportunities from the perspective of their potential application and contribution to cattle breeding. Harnessing the potential of this paradigm shift also poses some new challenges for animal scientists – and they will also be discusseden_GB
dc.description.sponsorshipM.P. Mullen was funded by a grant from Science Foundation Ireland (07/SRC/B1156).en_GB
dc.language.isoenen_GB
dc.publisherCambridge University Pressen_GB
dc.relation.ispartofseriesAnimal: The International Journal of Animal Biosciences;vol 5
dc.subject"omic"en_GB
dc.subjectSystems biologyen_GB
dc.subjectbreedingen_GB
dc.subjectApplicationen_GB
dc.titleThe integration of ‘omic’ disciplines and systems biology in cattle breedingen_GB
dc.typeArticleen_GB
dc.identifier.rmisMKAB-0201-5889
dc.identifier.doihttp://dx.doi.org/10.1017/S1751731110002120
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumber07/SRC/B1156
refterms.dateFOA2018-01-12T07:44:07Z


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