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dc.contributor.authorGuinane, Caitriona M.*
dc.contributor.authorCotter, Paul D.*
dc.date.accessioned2013-05-08T15:19:03Z
dc.date.available2014-04-01T16:00:05Z
dc.date.issued26/03/2013
dc.identifier.citationCaitriona M. Guinane and Paul D. Cotter. Role of gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ Therapeutic Advances in Gastroenterology, 1756283X13482996, first published on March 26, 2013 doi:10.1177/1756283X13482996en_GB
dc.identifier.issn1765-283X
dc.identifier.urihttp://hdl.handle.net/11019/389
dc.descriptionpeer-revieweden_GB
dc.description.abstractThe human gut microbiota has become the subject of extensive research in recent years and our knowledge of the resident species and their potential functional capacity is rapidly growing. Our gut harbours a complex community of over 100 trillion microbial cells which influence human physiology, metabolism, nutrition and immune function while disruption to the gut microbiota has been linked with gastrointestinal conditions such as inflammatory bowel disease and obesity. Here, we review the many significant recent studies that have centred on further enhancing our understanding of the complexity of intestinal communities as well as their genetic and metabolic potential. These have provided important information with respect to what constitutes a ‘healthy gut microbiota’ while furthering our understanding of the role of gut microbes in intestinal diseases. We also highlight recently developed genomic and other tools that are used to study the gut microbiome and, finally, we consider the manipulation of the gut microbiota as a potential therapeutic option to treat chronic gastrointestinal disease.en_GB
dc.description.sponsorshipScience Foundation Ireland (PI award 11/PI/1137)en_GB
dc.language.isoenen_GB
dc.publisherSage Publicationsen_GB
dc.relation.ispartofseriesTherapeutic Advances in Gastroenterology;
dc.subjectMicrobial diversityen_GB
dc.subjectGut healthen_GB
dc.subjectGastrointestinal diseaseen_GB
dc.subjectMicrobial manipulationen_GB
dc.titleRole of gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organen_GB
dc.typeArticleen_GB
dc.embargo.terms26/03/2014
dc.identifier.rmisMDBY-0106-6286
dc.identifier.doihttp://dx.doi.org/10.1177/1756283X13482996
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumberSFI/11/PI/1137
refterms.dateFOA2018-01-12T07:33:28Z


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