• Login
    View Item 
    •   T-Stór
    • Animal & Grassland Research & Innovation Programme
    • Animal & Bioscience
    • View Item
    •   T-Stór
    • Animal & Grassland Research & Innovation Programme
    • Animal & Bioscience
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of T-StórCommunitiesPublication DateAuthorsTitlesSubjectsFunderThis CollectionPublication DateAuthorsTitlesSubjectsFunderProfilesView

    My Account

    LoginRegister

    Information

    Deposit AgreementLicense

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Finlay_TB_GWAS.pdf
    Size:
    431.5Kb
    Format:
    PDF
    Download
    Author
    Finlay, Emma K.
    Berry, Donagh cc
    Wickham, Brian W.
    Gormley, Eamonn
    Bradley, Daniel G
    Keyword
    Bovine Tuberculosis
    Genetic component
    SNP genotypes
    Taurine transporter gene SLC6A6
    Susceptibility
    BTA 22
    Date
    2012-02
    
    Metadata
    Show full item record
    Statistics
    Display Item Statistics
    URI
    http://hdl.handle.net/11019/393
    Citation
    Finlay EK, Berry DP, Wickham B, Gormley EP, Bradley DG (2012) A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle. PLoS ONE 7(2): e30545. doi:10.1371/journal.pone.0030545
    Abstract
    Background: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and dissection of this may enlighten on the wider biology of host response to tuberculosis. However, a binary phenotype of presence/absence of infection presents a noisy signal for genomewide association study. Methodology/Principal Findings: We calculated a composite phenotype of genetic merit for TB susceptibility based on disease incidence in daughters of elite sires used for artificial insemination in the Irish dairy herd. This robust measure was compared with 44,426 SNP genotypes in the most informative 307 subjects in a genome wide association analysis. Three SNPs in a 65 kb genomic region on BTA 22 were associated (i.e. p,1025, peaking at position 59588069, p = 4.0261026) with tuberculosis susceptibility. Conclusions/Significance: A genomic region on BTA 22 was suggestively associated with tuberculosis susceptibility; it contains the taurine transporter gene SLC6A6, or TauT, which is known to function in the immune system but has not previously been investigated for its role in tuberculosis infection.
    Funder
    Department of Agriculture, Food and the Marine; Science Foundation Ireland; European Union
    Grant Number
    RSF 06409; 09/IN.1/B2642; KBBE-211602-MACROSYS
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1371/journal.pone.0030545
    Scopus Count
    Collections
    Animal & Bioscience

    entitlement

     
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.