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dc.contributor.authorBeecher, Christine*
dc.contributor.authorDaly, Mairead*
dc.contributor.authorBerry, Donagh*
dc.contributor.authorKlostermann, Katja*
dc.contributor.authorFlynn, James*
dc.contributor.authorMeaney, William J*
dc.contributor.authorHill, Colin*
dc.contributor.authorMcCarthy, Tommie V*
dc.contributor.authorRoss, R Paul*
dc.contributor.authorGiblin, Linda*
dc.date.accessioned2013-08-19T14:17:16Z
dc.date.available2013-08-19T14:17:16Z
dc.date.issued18/05/2009
dc.identifier.citationChristine Beecher, Mairéad Daly, Donagh P Berry, Katja Klostermann, James Flynn, William Meaney, Colin Hill, Tommie V McCarthy, R Paul Ross and Linda Giblin (2009). Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expression. Journal of Dairy Research, 76, pp 340-348. doi:10.1017/S0022029909004154.Copyright © Proprietors of Journal of Dairy Researchen_GB
dc.identifier.issn1469-7629
dc.identifier.urihttp://hdl.handle.net/11019/426
dc.descriptionpeer-revieweden_GB
dc.description.abstractMastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials, that a probiotic culture, Lactococcus lactis DPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed in Interleukin (IL)-1b and IL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of a Lc. lactis leads to a rapid and considerable innate immune response.en_GB
dc.language.isoenen_GB
dc.publisherCambridge University Press: Published for the Institute of Food Research and the Hannah Research Instituteen_GB
dc.relation.ispartofseriesJournal of Dairy Research;vol 76
dc.subjectMastitisen_GB
dc.subjectLactococcus lactisen_GB
dc.subjectProbiotic treatmenten_GB
dc.titleAdministration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expressionen_GB
dc.typeArticleen_GB
dc.identifier.rmisMDBY-0201-5463
dc.identifier.doihttp://dx.doi.org/10.1017/S0022029909004154
dc.contributor.sponsorIrish Dairy Levy Research Trust
dc.contributor.sponsorNational Development Plan
dc.contributor.sponsorTeagasc Walsh Fellowship Programme
refterms.dateFOA2018-01-12T07:45:40Z


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