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dc.contributor.authorFouhy, Fiona
dc.contributor.authorRoss, R Paul
dc.contributor.authorFitzgerald, Gerald F
dc.contributor.authorStanton, Catherine
dc.contributor.authorCotter, Paul D.
dc.date.accessioned2013-08-27T13:56:20Z
dc.date.available2013-08-27T13:56:20Z
dc.date.issued01/05/2012
dc.identifier.citationFouhy F, Ross RP, Fitzgerald GF, Stanton C, Cotter PD. Composition of the early intestinal microbiota: Knowledge, knowledge gaps and the use of high-throughput sequencing to address these gaps. Gut Microbes 2012; 3:203 - 220. DOI: 10.4161/gmic.20169en_GB
dc.identifier.issn1949-0976
dc.identifier.otherPMID: 22572829
dc.identifier.urihttp://hdl.handle.net/11019/437
dc.descriptionpeer-revieweden_GB
dc.description.abstractThe colonization, development and maturation of the newborn gastrointestinal tract that begins immediately at birth and continues for two years, is modulated by numerous factors including mode of delivery, feeding regime, maternal diet/weight, probiotic and prebiotic use and antibiotic exposure pre-, peri- and post-natally. While in the past, culture-based approaches were used to assess the impact of these factors on the gut microbiota, these have now largely been replaced by culture-independent DNA-based approaches and most recently, high-throughput sequencing-based forms thereof. The aim of this review is to summarize recent research into the modulatory factors that impact on the acquisition and development of the infant gut microbiota, to outline the knowledge recently gained through the use of culture-independent techniques and, in particular, highlight advances in high-throughput sequencing and how these technologies have, and will continue to, fill gaps in our knowledge with respect to the human intestinal microbiota.en_GB
dc.description.sponsorshipIrish Research Council for Science Engineering and Technology EMBARK scholarship; Teagasc Walsh Fellowship; Science Foundation of Ireland (SFI) funded Centre for Science, Engineering and Technology; SFI PI award ‘Obesibiotics’ (11/PI/1137).en_GB
dc.language.isoenen_GB
dc.publisherLandes Bioscienceen_GB
dc.relation.ispartofseriesGut Microbes;vol 3
dc.subjectAntibioticsen_GB
dc.subjectColonizationen_GB
dc.subjectGut microbiotaen_GB
dc.subjectHigh-throughput sequencingen_GB
dc.subjectInfanten_GB
dc.subjectPrebioticsen_GB
dc.subjectProbioticsen_GB
dc.titleComposition of the early intestinal microbiota: Knowledge, knowledge gaps and the use of high-throughput sequencing to address these gapsen_GB
dc.typeArticleen_GB
dc.identifier.rmisMDBY-0106-5971
dc.identifier.doihttp://dx.doi.org/10.4161/gmic.20169
dc.contributor.sponsorIrish Research Council for Science, Engineering and Technology
dc.contributor.sponsorTeagasc Walsh Fellowship Programme
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumber11/PI/1137
refterms.dateFOA2018-01-12T07:51:31Z


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