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dc.contributor.authorO'Loughlin, Ian B.*
dc.contributor.authorMurray, Brian A.*
dc.contributor.authorFitzgerald, Richard J.*
dc.contributor.authorBrodkorb, Andre*
dc.contributor.authorKelly, Philip*
dc.date.accessioned2013-12-11T16:10:01Z
dc.date.available2013-12-11T16:10:01Z
dc.date.issued13/08/2013
dc.identifier.citationI.B. O'Loughlin, B.A. Murray, R.J. FitzGerald, A. Brodkorb, P.M. Kelly. Pilot-scale production of hydrolysates with altered bio-functionalities based on thermally-denatured whey protein isolate. International Dairy Journal, 2014, 34(1), 146-152. DOI: 10.1016/j.idairyj.2013.07.009.en_GB
dc.identifier.issn0958-6946
dc.identifier.urihttp://hdl.handle.net/11019/475
dc.descriptionpeer-revieweden_GB
dc.description.abstractWhey protein isolate (WPI) solutions (100 g L−1 protein) were subjected to a heat-treatment of 80 °C for 10 min. Unheated and heat-treated WPI solutions were hydrolysed with Corolase® PP at pilot-scale to either 5 or 10% degree of hydrolysis (DH). Hydrolysates were subsequently processed via cascade membrane fractionation using 0.14 μm, and 30, 10, 5 and 1 kDa cut-off membranes. The compositional and molecular mass distribution profiles of the substrate hydrolysates and membrane processed fractions were determined. Whole and fractionated hydrolysates were assayed for both angiotensin-I-converting enzyme (ACE) inhibitory activity and ferrous chelating capabilities. A strong positive correlation (P < 0.01) was established between the average molecular mass of the test samples and the concentration needed to chelate 50% of the iron (CC50) in solution. The lowest ACE inhibition concentration (IC50 = 0.23 g L−1 protein) was determined for the 1 kDa permeate of the heat-treated 10% DH hydrolysateen_GB
dc.description.sponsorshipThe work herein was funded by Enterprise Ireland as part of the Food for Health Ireland project, grant number; CC20080001. I. B. O’Loughlin was funded by Enterprise Ireland under the Teagasc Walsh Fellowship Scheme.
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.ispartofseriesInternational Dairy Journal;vol 34
dc.subjectHydrolysisen_GB
dc.subjectACEen_GB
dc.subjectIron-bindingen_GB
dc.subjectPilot-scaleen_GB
dc.subjectBio-functional hydrolysatesen_GB
dc.subjectHeat-treatmenten_GB
dc.titlePilot-scale Production of Hydrolysates with Altered Bio-functionalities based on Thermally-denatured Whey Protein Isolateen_GB
dc.typeArticleen_GB
dc.identifier.rmisMDDT-0106-5940
dc.identifier.doihttp://dx.doi.org/10.1016/j.idairyj.2013.07.009
dc.contributor.sponsorEnterprise Ireland
dc.contributor.sponsorTeagasc Walsh Fellowship Programme
dc.contributor.sponsorGrantNumberCC20080001
refterms.dateFOA2018-01-12T07:52:00Z


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