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dc.contributor.authorFares, Mario A
dc.contributor.authorKeane, Orla M
dc.contributor.authorToft, Christina
dc.contributor.authorCarretero-Paulet, Lorenzo
dc.contributor.authorJones, Gary W
dc.date.accessioned2014-01-09T11:54:15Z
dc.date.available2014-01-09T11:54:15Z
dc.date.issued2013-01-03
dc.identifier.citationFares MA, Keane OM, Toft C, Carretero-Paulet L, and Jones GW. 2013. The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes. PLoS Genetics 9 (1): e1003176. doi:10.1371/journal.pgen.1003176en_GB
dc.identifier.issn1553-7390
dc.identifier.urihttp://hdl.handle.net/11019/485
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pgen.1003176
dc.descriptionpeer-revieweden_GB
dc.descriptionThis study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of distribution of mutations in duplicates and their possible effects on fitness was supported by a grant from the Ministerio de Ciencia e Innovacion (BFU2009-12022) to MAF. CT is supported by a long-term postdoctoral EMBO fellowship (EMBO ALTF 730-2011).
dc.description.abstractResearchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic interactions than singletons and WGD-duplicates; (b) SSD-duplicates copies share more interaction-partners than WGD-duplicates copies; (c) WGDduplicates interaction partners are more functionally related than SSD-duplicates partners; (d) SSD-duplicates gene copies are more functionally divergent from one another, while keeping more overlapping functions, and diverge in their subcellular locations more than WGD-duplicates copies; and (e) SSD-duplicates complement their functions to a greater extent than WGD–duplicates. We propose a novel model that uncovers the complexity of evolution after gene duplicationen_GB
dc.description.sponsorshipScience Foundation Irelanden_GB
dc.description.sponsorshipMinisterio de Ciencia e Innovacion
dc.description.sponsorshipEuropean Molecular Biology Organization
dc.language.isoenen_GB
dc.publisherPLoSen_GB
dc.relation.ispartofseriesPLoS Genetics;vol 9
dc.subjectGene duplicationen_GB
dc.subjectWhole-genome duplicationsen_GB
dc.subjectSmall-scale duplicationsen_GB
dc.subjectSaccharomyces cerevisiae genomeen_GB
dc.titleThe Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genesen_GB
dc.typeArticleen_GB
dc.identifier.rmisGEAB-1002-5694
refterms.dateFOA2018-01-12T07:54:07Z


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