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    Detection of banned nitrofuran metabolites in animal plasma samples using UHPLC–MS/MS

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    JCB 2011 879 p159 TStor.pdf
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    Author
    Radovnikovic, Anita
    Moloney, Mary
    Byrne, Patrick
    Danaher, Martin
    Keyword
    Nitrofuran metabolites
    Plasma
    Residue determination
    UHPLC–MS/MS
    Stability study
    Date
    2010-12-07
    
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    URI
    http://hdl.handle.net/11019/488
    Citation
    Anita Radovnikovic, Mary Moloney, Paddy Byrne, Martin Danaher. Detection of banned nitrofuran metabolites in animal plasma samples using UHPLC–MS/MS. Journal of Chromatography B, 2011, 879(2), 159-166. DOI: 10.1016/j.jchromb.2010.11.036.
    Abstract
    The use of nitrofurans as veterinary drugs in food-producing animals has been banned in the EU since the 1990s. Monitoring programs in the EU are based on the detection of protein-bound metabolites after slaughter. An UHPLC–MS/MS method was developed and validated for pre slaughter determination of four nitrofuran metabolites (AHD, AOZ, SEM, AMOZ) in animal plasma (bovine, ovine, equine and porcine). This method is proposed as an alternative method for on-farm surveillance. Plasma samples were derivatised with 2-nitrobenzaldehyde and subsequently extracted with organic solvent. Extracts were concentrated and then analysed by UHPLC–MS/MS. The method was validated according to Commission Decision 2002/657/EC. Inter-species recovery for AHD, AOZ, SEM and AMOZ was 72, 74, 57 and 71%, respectively. Decision limits (CC ) were calculated from within laboratory reproducibility experiments to be 0.070, 0.059, 0.071 and 0.054 gkg−1, respectively. In addition, the assay was applied to incurred plasma samples taken from pigs treated with furazolidone.
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1016/j.jchromb.2010.11.036
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