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dc.contributor.authorKeegan, Jemma
dc.contributor.authorWhelan, Michelle
dc.contributor.authorDanaher, Martin
dc.contributor.authorCrooks, Steven
dc.contributor.authorSayers, Riona
dc.contributor.authorAnastasio, Aniello
dc.contributor.authorElliott, Chrtistopher
dc.contributor.authorBrandon, David
dc.contributor.authorFurey, Ambrose
dc.contributor.authorO'Kennedy, Richard
dc.date.accessioned2014-01-10T11:37:42Z
dc.date.available2014-01-10T11:37:42Z
dc.date.issued2009-09-26
dc.identifier.citationJemma Keegan, Michelle Whelan, Martin Danaher, Steven Crooks, Regina Sayers, Aniello Anastasio, Christopher Elliott, David Brandon, Ambrose Furey, Richard O’Kennedy. Benzimidazole carbamate residues in milk: Detection by Surface Plasmon Resonance-biosensor, using a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method for extraction. Analytica Chimica Acta, 2009, 654(2), 111-119. DOI: 10.1016/j.aca.2009.09.028.en_GB
dc.identifier.issn0003-2670
dc.identifier.urihttp://hdl.handle.net/11019/489
dc.descriptionpeer-revieweden_GB
dc.description.abstractA surface plasmon resonance (SPR) biosensor screening assay was developed and validated to detect 11 benzimidazole carbamate (BZT) veterinary drug residues in milk. The polyclonal antibody used was raised in sheep against a methyl 5(6)-[(carboxypentyl)-thio]-2-benzimidazole carbamate protein conjugate. A sample preparation procedure was developed using a modified QuEChERS method. BZT residues were extracted from milk using liquid extraction/partition with a dispersive solid phase extraction clean-up step. The assay was validated in accordance with the performance criteria described in 2002/657/EC. The limit of detection of the assay was calculated from the analysis of 20 known negative milk samples to be 2.7 μg kg−1. The detection capability (CCβ) of the assay was determined to be 5 μg kg−1 for 11 benzimidazole residues and the mean recovery of analytes was in the range 81–116%. A comparison was made between the SPR-biosensor and UPLC–MS/MS analyses of milk samples (n = 26) taken from cows treated different benzimidazole products, demonstrating the SPR-biosensor assay to be fit for purpose.en_GB
dc.description.sponsorshipDepartment of Agriculture, Food and the Marineen_GB
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.ispartofseriesAnalytica Chimica Acta;vol 654
dc.subjectSPR-biosensorsen_GB
dc.subjectBenzimidazole carbamatesen_GB
dc.subjectBovine milken_GB
dc.subjectQuEChERSen_GB
dc.titleBenzimidazole carbamate residues in milk: Detection by Surface Plasmon Resonance-biosensor, using a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method for extractionen_GB
dc.typeArticleen_GB
dc.identifier.doihttp://dx.doi.org/10.1016/j.aca.2009.09.028
refterms.dateFOA2018-01-12T07:54:55Z
atmire.accessrightsDepartment of Agriculture, Food and the Marine


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