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    The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid

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    Author
    Brinkman, Christel Rothe
    Brodkorb, Andre cc
    Thiel, Steffen
    Kehoe, Joseph James
    Keyword
    Alpha lactalbumin
    Cytotoxicity
    Fatty acids
    HAMLET
    Oleic Acid
    Date
    17/04/2013
    
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    URI
    http://hdl.handle.net/11019/576
    Citation
    Brinkmann, C. R., Brodkorb, A., Thiel, S. and Kehoe, J. J. (2013), The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid. Eur. J. Lipid Sci. Technol., 115: 591–600. doi: 10.1002/ejlt.201200165
    Abstract
    Complexes of the milk protein, α-lactalbumin, and the fatty acid, oleic acid, have previously been shown to be cytotoxic. Complexes of α-lactalbumin and five different fatty acids (vaccenic, linoleic, palmitoleic, stearic, and elaidic acid) were prepared and compared to those formed with oleic acid. All complexes were cytotoxic to human promyelocytic leukemia-derived (HL-60) cells but to different degrees depending on the fatty acid. The amount of fatty acid per α-lactalbumin molecule was found to correlate with the cytotoxicity; the higher the number of fatty acids per protein, the more cytotoxic the complex. Importantly, all the tested fatty acids were also found to be cytotoxic on their own in a concentration dependent manner. The cytotoxic effect of complexes between α-lactalbumin and linoleic acid, vaccenic acid, or oleic acid was further investigated using flow cytometry and found to induce cell death resembling apoptosis on Jurkat cells. Practical applications: Cytotoxic complexes of α-lactalbumin and several different fatty acids could be produced. The cytotoxicity of all the variants is similar to that previously determined for α-lactalbumin/oleic acid complexes.
    Funder
    Department of Agriculture, Food and the Marine
    Grant Number
    08RDTMFRC650
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1002/ejlt.201200165
    Scopus Count
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    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Chemistry & Technology

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