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dc.contributor.authorWalsh, Calum J.*
dc.contributor.authorGuinane, Caitriona M.*
dc.contributor.authorO'Toole, Paul W.*
dc.contributor.authorCotter, Paul D.*
dc.date.accessioned2014-05-01T13:44:53Z
dc.date.available2014-05-01T13:44:53Z
dc.date.issued26/03/2014
dc.identifier.citationCalum J. Walsh, Caitriona M. Guinane, Paul W. O’Toole, Paul D. Cotter, Beneficial modulation of the gut microbiota, FEBS Letters, Available online 26 March 2014, http://dx.doi.org/10.1016/j.febslet.2014.03.035.en_GB
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/11019/577
dc.descriptionpeer-revieweden_GB
dc.description.abstractThe human gut microbiota comprises approximately 100 trillion microbial cells and has a significant effect on many aspects of human physiology including metabolism, nutrient absorption and immune function. Disruption of this population has been implicated in many conditions and diseases, including examples such as obesity, inflammatory bowel disease and colorectal cancer that are highlighted in this review. A logical extension of these observations suggests that the manipulation of the gut microbiota can be employed to prevent or treat these conditions. Thus, here we highlight a variety of options, including the use of changes in diet (including the use of prebiotics), antimicrobial-based intervention, probiotics and faecal microbiota transplantation, and discuss their relative merits with respect to modulating the intestinal community in a beneficial way.en_GB
dc.description.sponsorshipC.J.W, C.M.G. and P.D.C are supported by a SFI PI award “Obesibiotics” (11/PI/1137)en_GB
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.ispartofseriesFEBS Letters;
dc.subjectMicrobiotaen_GB
dc.subjectGut Healthen_GB
dc.subjectMicrobial modulationen_GB
dc.subjectFaecal microbiota transplantationen_GB
dc.subjectDieten_GB
dc.subjectAntimicrobialen_GB
dc.titleBeneficial modulation of the gut microbiotaen_GB
dc.typeArticleen_GB
dc.identifier.rmis6286
dc.identifier.doihttp://dx.doi.org/10.1016/j.febslet.2014.03.035
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumber11/PI/1137
refterms.dateFOA2018-01-12T07:51:50Z


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