• Draft Genome Sequences of Macrococcus caseolyticus, Macrococcus canis, Macrococcus bohemicus, and Macrococcus goetzii

      Mazhar, Shahneela; Altermann, Eric; Hill, Colin; McAuliffe, Olivia; Teagasc Walsh Fellowship Programme; 2015055 (American Society for Microbiology, 2019-05-09)
      Here, we present the draft genome sequences of 14 strains of 4 species of the genus Macrococcus. These strains were isolated from bovine milk and tongue samples obtained during a screening program.
    • Draft Genome Sequences of Macrococcus caseolyticus, Macrococcus canis, Macrococcus bohemicus, and Macrococcus goetzii

      Mazhar, Shahneela; Altermann, Eric; Hill, Colin; McAuliffe, Olivia; Teagasc Walsh Fellowship Programme; Teagasc; 2015055; 6697 (American Society for Microbiology, 2019-05-09)
      Here, we present the draft genome sequences of 14 strains of 4 species of the genus Macrococcus. These strains were isolated from bovine milk and tongue samples obtained during a screening program.
    • Draft Genome Sequences of the Type Strains of Six Macrococcus Species

      Mazhar, Shahneela; Altermann, Eric; Hill, Colin; McAuliffe, Olivia; Teagasc Walsh Fellowship Programme; 2015055 (American Society for Microbiology, 2019-05-09)
      We report here the draft genome sequences of Macrococcus bovicus ATCC 51825T, Macrococcus carouselicus ATCC 51828T, Macrococcus equipercicus ATCC 51831T, Macrococcus brunensis CCM4811T, Macrococcus hajekii CCM4809T, and Macrococcus lamae CCM4815T. The availability of the genome sequences of these species will enable cross-species comparison, which could lead to a more comprehensive understanding of organisms of the Macrococcus genus.
    • Draft Genome Sequences of the Type Strains of Six Macrococcus Species

      Mazhar, Shahneela; Altermann, Eric; Hill, Colin; McAuliffe, Olivia; Teagasc Walsh Fellowship Programme; Teagasc; 2015055; 6697 (American Society for Microbiology, 2019-05-09)
      We report here the draft genome sequences of Macrococcus bovicus ATCC 51825T, Macrococcus carouselicus ATCC 51828T, Macrococcus equipercicus ATCC 51831T, Macrococcus brunensis CCM4811T, Macrococcus hajekii CCM4809T, and Macrococcus lamae CCM4815T. The availability of the genome sequences of these species will enable cross-species comparison, which could lead to a more comprehensive understanding of organisms of the Macrococcus genus.
    • Extensive bacteriocin gene shuffling in the Streptococcus bovis/Streptococcus equinus complex reveals gallocin D with activity against vancomycin resistant enterococci

      Hill, Daragh; O’Connor, Paula M.; Altermann, Eric; Day, Li; Hill, Colin; STANTON, CATHERINE; Ross, Paul; Teagasc Walsh Fellowship Programme; Science Foundation Ireland; SFI/12/RC/2273 (Springer Science and Business Media LLC, 2020-08-10)
      Streptococcus gallolyticus LL009 produces gallocin D, a narrow spectrum two component bacteriocin with potent activity against vancomycin-resistant enterococci. Gallocin D is distinct from gallocin A, a separate two component bacteriocin produced by S. gallolyticus. Although the gene clusters encoding gallocin A and gallocin D have a high degree of gene synteny, the structural genes are highly variable and appear to have undergone gene shufing with other streptococcal species. Gallocin D was analysed in laboratory-based experiments. The mature peptides are 3,343± 1 Da and 3,019 ± 1 Da and could be readily synthesized and display activity against a vancomycin resistant Enterococcus strain EC300 with a MIC value of 1.56 µM. Importantly, these bacteriocins could contribute to the ability of S. gallolyticus to colonize the colon where they have been associated with colorectal cancer.