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dc.contributor.authorKeating, A.F.*
dc.contributor.authorSmith, T.J.*
dc.contributor.authorRoss, R Paul*
dc.contributor.authorCairns, M.T.*
dc.date.accessioned2014-07-24T11:52:58Z
dc.date.available2014-07-24T11:52:58Z
dc.date.issued2008
dc.identifier.citationA.F. Keating, T.J. Smith, R.P. Ross and M.T. Cairns. A note on the evaluation of a beta-casein variant in bovine breeds by allele-specific PCR and relevance to β-casomorphin. Irish Journal of Agricultural and Food Research 47: 99–104, 2008en_GB
dc.identifier.issn0791-6833
dc.identifier.urihttp://hdl.handle.net/11019/632
dc.descriptionpeer-revieweden_GB
dc.descriptionThis work was supported by Enterprise Ireland and by a Teagasc Walsh fellowship to A.F. Keating.
dc.description.abstractTwo genetic variants of the bovine β-casein gene (A1 and B) encode a histidine residue at codon 67, resulting in potential liberation of a bioactive peptide, β-casomorphin, upon digestion. An allele-specific PCR (AS-PCR) was evaluated to distinguish between the β-casomorphin-releasing variants (A1 and B) and the non-releasing variants. AS-PCR successfully distinguished β-casein variants in 41 of 42 animals as confirmed by sequence analysis. Overall, while the incidence of the homozygous A1 and B animals (i.e., homozygous for the histidine residue; 21.4%) was lower than that for animals without the histidine residue (30.9% respectively), 69% of animals carried at least one allele for the histidine residue at codon 67.en_GB
dc.description.sponsorshipTeagasc Walsh Fellowship Programmeen_GB
dc.description.sponsorshipEnterprise Ireland
dc.languageEnglish
dc.language.isoenen_GB
dc.publisherTeagasc, Oak Park, Carlow, Irelanden_GB
dc.relation.ispartofseriesIrish Journal of Agricultural and Food Research;vol 47
dc.subjectAllele-specific PCRen_GB
dc.subjectβ-caseinen_GB
dc.subjectBioactive peptidesen_GB
dc.titleA note on the evaluation of a beta-casein variant in bovine breeds by allele-specific PCR and relevance to β-casomorphinen_GB
dc.typeArticleen_GB
refterms.dateFOA2018-01-12T07:25:34Z


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