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    Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes

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    Author
    Cotter, Paul D.
    Draper, Lorraine A.
    Lawton, Elaine M.
    Daly, Karen M.
    Groeger, David S.
    Casey, Patrick G.
    Ross, R Paul
    Hill, Colin
    Keyword
    Bacterial pathogens
    Listeria monocytogenes
    Haemolysin
    Listeriosis
    Genome evolution
    Virulence factors
    Date
    12/09/2008
    
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    URI
    http://hdl.handle.net/11019/712
    Citation
    Cotter PD, Draper LA, Lawton EM, Daly KM, Groeger DS, et al. (2008) Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes. PLoS Pathog 4(9): e1000144. doi:10.1371/journal.ppat.1000144
    Abstract
    Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including Listeria monocytogenes, Clostridium botulinum and Staphylococcus aureus, produce related peptides. The distribution of the L. monocytogenes cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil–based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L. monocytogenes may have been revealed.
    Funder
    Science Foundation Ireland
    Grant Number
    06/IN.1/B98
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1371/journal.ppat.1000144
    Scopus Count
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    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Biosciences

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