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dc.contributor.authorCotter, Paul D.*
dc.contributor.authorDraper, Lorraine A.*
dc.contributor.authorLawton, Elaine M.*
dc.contributor.authorDaly, Karen M.*
dc.contributor.authorGroeger, David S.*
dc.contributor.authorCasey, Patrick G.*
dc.contributor.authorRoss, R Paul*
dc.contributor.authorHill, Colin*
dc.date.accessioned2014-08-25T14:04:27Z
dc.date.available2014-08-25T14:04:27Z
dc.date.issued12/09/2008
dc.identifier.citationCotter PD, Draper LA, Lawton EM, Daly KM, Groeger DS, et al. (2008) Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes. PLoS Pathog 4(9): e1000144. doi:10.1371/journal.ppat.1000144en_GB
dc.identifier.urihttp://hdl.handle.net/11019/712
dc.descriptionpeer-revieweden_GB
dc.description.abstractStreptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including Listeria monocytogenes, Clostridium botulinum and Staphylococcus aureus, produce related peptides. The distribution of the L. monocytogenes cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil–based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L. monocytogenes may have been revealed.en_GB
dc.description.sponsorshipWork is funded by the Irish Government under the National Development Plan, through a Science Foundation Ireland Investigator award to CH, PR and PC (06/IN.1/B98).en_GB
dc.language.isoenen_GB
dc.publisherPLOSen_GB
dc.relation.ispartofseriesPLoS Pathogens;vol 4
dc.subjectBacterial pathogensen_GB
dc.subjectListeria monocytogenesen_GB
dc.subjectHaemolysinen_GB
dc.subjectListeriosisen_GB
dc.subjectGenome evolutionen_GB
dc.subjectVirulence factorsen_GB
dc.titleListeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenesen_GB
dc.typeArticleen_GB
dc.identifier.rmisMDBY-0106-5271
dc.identifier.doihttp://dx.doi.org/10.1371/journal.ppat.1000144
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumber06/IN.1/B98
refterms.dateFOA2018-01-12T08:04:15Z


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