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    Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance

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    Author
    McRae, Kathryn M.
    Good, Barbara
    Hanrahan, James P
    Glynn, Assumpta
    O'Connell, Mary J.
    Keane, Orla M
    Keyword
    Scottish Blackface
    Sheep
    Teladorsagia circumcincta
    Host–parasite interaction
    Nematode resistance
    IgA
    Date
    2014-10-24
    
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    URI
    http://hdl.handle.net/11019/768
    Citation
    Kathryn M. McRae, Barbara Good, James P. Hanrahan, Assumpta Glynn, Mary J. O’Connell, Orla M. Keane. Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance. Veterinary Parasitology, Volume 206, Issues 3–4, 15 December 2014, Pages 200-207. DOI: 10.1016/j.vetpar.2014.10.023
    Abstract
    The objective of this study was to identify Scottish Blackface lambs that were at the extremes of the spectrum of resistance to gastrointestinal nematodes and characterise their response to an experimental nematode challenge. Lambs (n = 90) were monitored for faecal egg count (FEC) (2 samples from each of 2 independent natural infections). The most resistant (n = 10) and susceptible (n = 10) individuals were selected and challenged with 30,000 Teladorsagia circumcincta larvae (L3) at 9 months of age. Response to infection was monitored by measuring FEC, plasma pepsinogen, serum antibodies against nematode larval antigens and haematology profile, until necropsy at 71 days post infection. Worm burden, worm fecundity and the level of anti-nematode antibodies in abomasal mucosa were determined at necropsy. FEC was consistently higher in susceptible animals (P < 0.05), validating the selection method. Worm fecundity was significantly reduced in resistant animals (P = 0.03). There was also a significant correlation (r = 0.88; P < 0.001) between the number of adult worms and FEC at slaughter. There was no effect of phenotype (resistance/susceptibility) on plasma pepsinogen or on haematology profile. Phenotype had a significant effect on the level of anti-nematode IgA antibodies in serum (P < 0.01), reflecting a higher peak in resistant animals at day 7 post infection. It is concluded that significant variation in the response to gastrointestinal nematode challenge exists within the Scottish Blackface population with resistant animals displaying significantly lower FEC, lower worm fecundity and higher concentration of anti-nematode IgA antibodies in serum.
    Funder
    Teagasc Walsh Fellowship Programme; Allan and Grace Kay Overseas Scholarship
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1016/j.vetpar.2014.10.023
    Scopus Count
    Collections
    Livestock Systems
    Animal & Bioscience

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